Dietary docosahexaenoic acid dose not promote lipid peroxidation in rat tissue to the extent expected from peroxidizability index of the lipids
Dietary docosahexaenoic acid dose not promote lipid peroxidation in rat tissue to the extent expected from peroxidizability index of the lipids
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DOI：
10.1271/bbb.62.1698
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发表时间：
1998-09-01
影响因子：
1.6
通讯作者：
Maekawa, A
中科院分区：
文献类型：
--
作者：
Kubo, K;Saito, M;Maekawa, A
二十二碳六烯酸（DHA）的摄入增加了大鼠肝脏和肾脏对脂质过氧化的敏感性，这是膳食DHA水平的函数，但通过硫代巴比妥酸（TBA）值评估，脂质过氧化并未增加到组织总脂质过氧化指数所期望的水平。这种现象在肝脏中尤为突出。在肝脏中，非磷类脂质中较高比例的DHA可能对降低组织对脂质过氧化的敏感性起重要作用。另一方面，在大脑和睾丸中，当给动物摄入DHA时，脂质过氧化水平降低了。特别是在睾丸中，即使摄入了相对较高的DHA， DHA在总脂质的比例在所有被检查的组织中也是最低的，这可能与低脂质过氧化水平有关。因此，对脂质过氧化的保护因组织而异，甚至从组织脂质的脂肪酸组成的观点来看也是如此。此外，通过TEA值评估的肝、肾、脑和睾丸的脂质过氧化水平的变化似乎与各组织中磷脂酰胆碱（+心磷脂）过氧化性指数的变化有关。
Docosahexaenoic acid (DHA) ingestion enhanced the susceptibility of rat liver and kidney to lipid peroxidation as a function of the dietary DHA level, but did not increase lipid peroxides as assessed by thiobarbituric acid (TBA) values to the level expected from the peroxidizability index of the tissue total lipids. This phenomenon was especially prominent in the liver. In the liver, the higher proportion of DHA in the non-phosphorus lipids might play an important role in lessening the susceptibility of the tissue to lipid peroxidation. In the brain and testis, on the other hand, lipid peroxide levels were decreased when DHA was given to the animals, In the testis, in particular, the proportion of DHA in total lipids was lowest among all tissues examined, even when a relatively high level of DHA had been ingested, and this could be related to the low lipid peroxide level. Therefore, the protection against lipid peroxidation differed from tissue to tissue, even from the viewpoint of the fatty acid composition of the tissue lipids. In addition, changes in the lipid peroxide levels of the liver, kidney, brain and testis, as assessed by TEA values, seemed to be associated with changes in the peroxidizability index of phosphatidylcholine (+ cardiolipin) in each tissue.