Renal metabolism of drugs and xenobiotics.
Renal metabolism of drugs and xenobiotics.
复制标题
药物和外源性物质的肾脏代谢。
作者：
Davis,BB;Mattammal,MB;Zenser,TV
肾皮质、外髓质和内髓质表现出不同的药物代谢特征。皮层有混合性氧化酶活性，髓质内无。前列腺素内过氧化物合成酶在内髓质中检测到协同作用，而在皮层中未检测到。外髓质中存在混合氧化酶和协同氧化酶。前列腺素内过氧化物合成酶可将FANFT、联苯胺等膀胱致癌物和肾癌致癌物己烯雌酚共氧化。协同氧化可能是一种激活膀胱致癌物质和肾毒性物质的机制。
The renal cortex, outer medulla and inner medulla exhibit different profiles of drug metabolism. Mixed-function oxidase activity was present in cortex but not inner medulla. Cooxidation by prostaglandin endoperoxide synthetase was detected in inner medulla but not cortex. Both mixed-function oxidase and cooxidation were demonstrable in outer medulla. Urinary bladder carcinogens such as FANFT and benzidine and the renal carcinogen diethylstilbestrol were cooxidized by prostaglandin endoperoxide synthetase. Cooxidation could be a mechanism of activation of urinary bladder carcinogens and of nephrotoxic agents.