Patterns of alcohol consumption and the metabolic syndrome
Patterns of alcohol consumption and the metabolic syndrome
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DOI：
10.1210/jc.2007-2788
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发表时间：
2008-10-01
影响因子：
5.8
通讯作者：
Mokdad, Ali H.
中科院分区：
文献类型：
--
作者：
Fan, Amy Z.;Russell, Marcia;Mokdad, Ali H.
背景和目的：饮酒与代谢综合征之间有保护和有害的关联。这可能是由于饮酒模式的不同以及酒精对代谢综合征成分的不同影响。本研究旨在研究饮酒模式与代谢综合征之间的关系。设计、设置、参与者和测量：1999-2002年全国健康和营养检查调查是一项以非机构的美国成年人为基础的人口调查。目前饮酒者年龄在20-84岁之间，无心血管疾病，且有代谢综合征和饮酒模式的完整数据（n = 1529）。代谢异常包括以下三种：空腹血糖/糖尿病、高甘油三酯、腹部肥胖、高血压和低高密度脂蛋白胆固醇。酒精消耗量的测量包括通常的消耗量、饮酒频率和酗酒频率。结果:在控制人口统计学、心血管疾病和糖尿病家族史以及生活方式因素的多项logistic回归模型中，代谢综合征的风险增加与每日饮酒量超过美国膳食指南建议（女性每天饮酒超过1杯，男性每天饮酒超过2杯）相关(优势比1.60，95%可信区间1.22-2.11)和每周酗酒一次或更多[优势比（95%可信区间）1.51(1.01-2.29)]。就个体代谢异常而言，饮酒过量与空腹血糖/糖尿病、高甘油三酯血症、腹部肥胖和高血压的风险增加有关。结论：公共卫生信息应强调与饮酒超过国家指南和酗酒相关的潜在心脏代谢风险。
Context and Objective: Protective and detrimental associations have been reported between alcohol consumption and the metabolic syndrome. This may be due to variations in drinking patterns and different alcohol effects on the metabolic syndrome components. This study is designed to examine the relationship between alcohol consumption patterns and the metabolic syndrome.Design, Setting, Participants, and Measures: The 1999-2002 National Health and Nutrition Examination Survey is a population-based survey of noninstitutionalized U. S. adults. Current drinkers aged 20-84 yr without cardiovascular disease who had complete data on the metabolic syndrome and drinking patterns were included in the analysis (n = 1529). The metabolic abnormalities comprising the metabolic syndrome included having three of the following: impaired fasting glucose/diabetes mellitus, high triglycerides, abdominal obesity, high blood pressure, and low high-density-lipoprotein cholesterol. Measures of alcohol consumption included usual quantity consumed, drinking frequency, and frequency of binge drinking.Results: In multinomial logistic regression models controlling for demographics, family history of cardiovascular disease and diabetes, and lifestyle factors, increased risk of the metabolic syndrome was associated with daily consumption that exceeded U. S. dietary guideline recommendations (more than one drink per drinking day for women and more than two drinks per drinking day for men (odds ratio 1.60, 95% confidence interval 1.22-2.11) and binge drinking once per week or more [ odds ratio (95% confidence interval) 1.51 (1.01-2.29]. By individual metabolic abnormality, drinking in excess of the dietary guidelines was associated with an increased risk of impaired fasting glucose/diabetes mellitus, hypertriglyceridemia, abdominal obesity, and high blood pressure.Conclusion: Public health messages should emphasize the potential cardiometabolic risk associated with drinking in excess of national guidelines and binge drinking.