MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data.
MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data.
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DOI：
10.1093/ije/dyx034
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发表时间：
2017-12-01
影响因子：
7.7
通讯作者：
Burgess S
中科院分区：
文献类型：
--
作者：
Yavorska OO;Burgess S
孟德尔随机化是一个用于R开源软件环境的软件包，它使用汇总的数据执行孟德尔随机化分析。其核心功能是实现多个遗传变异的逆方差加权、MR-Egger和加权中位数方法。用户可以使用几种选择，例如使用稳健回归、固定或随机效应模型，以及对具有不同因果估计的遗传变量的权重进行惩罚。如果合适的话，可以选择对这些方法的扩展，例如允许相关的变体。图形命令允许将汇总数据显示在交互式图形中，或绘制来自多种方法的因果估计，以供比较。虽然数据录入的主要方法是由用户直接输入，但也有一个选项，允许从PhenoScanner数据库中合并基因型-表型关联的汇总数据。我们希望在该程序包的未来版本中开发此功能。R软件环境可从[https://www.r-project.org/].]下载Mendelian随机化包可从R内的全面R档案网(CRAN)下载，或直接从[https://cran.r-project.org/web/packages/MendelianRandomization/].下载R和MendelianRandomization包都是在GNU通用公共许可证(GPL-2|GPL-3)下发布的。
MendelianRandomization is a software package for the R open-source software environment that performs Mendelian randomization analyses using summarized data. The core functionality is to implement the inverse-variance weighted, MR-Egger and weighted median methods for multiple genetic variants. Several options are available to the user, such as the use of robust regression, fixed- or random-effects models and the penalization of weights for genetic variants with heterogeneous causal estimates. Extensions to these methods, such as allowing for variants to be correlated, can be chosen if appropriate. Graphical commands allow summarized data to be displayed in an interactive graph, or the plotting of causal estimates from multiple methods, for comparison. Although the main method of data entry is directly by the user, there is also an option for allowing summarized data to be incorporated from the PhenoScanner database of genotype—phenotype associations. We hope to develop this feature in future versions of the package. The R software environment is available for download from [https://www.r-project.org/]. The MendelianRandomization package can be downloaded from the Comprehensive R Archive Network (CRAN) within R, or directly from [https://cran.r-project.org/web/packages/MendelianRandomization/]. Both R and the MendelianRandomization package are released under GNU General Public Licenses (GPL-2|GPL-3).
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影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
1.2
作者：
Thompson, John R.;Minelli, Cosetta;Del Greco, Fabiola M.
通讯作者：
Del Greco, Fabiola M.
DOI：
10.1097/ede.0000000000000559
发表时间：
2017-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Burgess S;Bowden J;Fall T;Ingelsson E;Thompson SG
通讯作者：
Thompson SG
DOI：
10.1161/atvbaha.109.201020
发表时间：
2010-11
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Waterworth DM;Ricketts SL;Song K;Chen L;Zhao JH;Ripatti S;Aulchenko YS;Zhang W;Yuan X;Lim N;Luan J;Ashford S;Wheeler E;Young EH;Hadley D;Thompson JR;Braund PS;Johnson T;Struchalin M;Surakka I;Luben R;Khaw KT;Rodwell SA;Loos RJ;Boekholdt SM;Inouye M;Deloukas P;Elliott P;Schlessinger D;Sanna S;Scuteri A;Jackson A;Mohlke KL;Tuomilehto J;Roberts R;Stewart A;Kesäniemi YA;Mahley RW;Grundy SM;Wellcome Trust Case Control Consortium;McArdle W;Cardon L;Waeber G;Vollenweider P;Chambers JC;Boehnke M;Abecasis GR;Salomaa V;Järvelin MR;Ruokonen A;Barroso I;Epstein SE;Hakonarson HH;Rader DJ;Reilly MP;Witteman JC;Hall AS;Samani NJ;Strachan DP;Barter P;van Duijn CM;Kooner JS;Peltonen L;Wareham NJ;McPherson R;Mooser V;Sandhu MS
通讯作者：
Sandhu MS