Does bone loss begin after weight loss ends? Results 2 years after weight loss or regain in postmenopausal women.
Does bone loss begin after weight loss ends? Results 2 years after weight loss or regain in postmenopausal women.
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减肥结束后骨质会开始流失吗？
DOI：
10.1097/gme.0b013e3182a76fd5
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Shapses,SueA
中科院分区：
文献类型：
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作者：
VonThun,NancyL;Sukumar,Deeptha;Heymsfield,StevenB;Shapses,SueA
ObjectiveShort-term weight loss is accompanied by bone loss in postmenopausal women. The longer-term impact of weight loss on bone in reduced overweight/obese women compared with women who regained their weight was examined in this study using a case-control design.MethodsPostmenopausal women (N= 42; mean [SD] body mass index, 28.3 [2.8] kg/m 2; mean [SD] age, 60.7 [5.5] y) were recruited 2 years after the start of a 6-month weight loss trial; those who maintained their weight (weight loss maintainer [WL-M] group) were matched to a cohort of women who regained their weight (weight loss regainer [WL-R] group). Serum hormones and bone markers were measured in a subset. Bone mineral density (BMD) at the femoral neck, trochanter, spine, radius, and total body, and soft-tissue composition were taken at baseline, 0.5 years, and 2 years.ResultsDuring weight loss, both groups lost 9.3%(3.4%) of body weight, with no significant difference between the groups. After weight loss, weight change was− 0.1%(2.7%) and 6.0%(3.3%) in the WL-M (n= 22) and WL-R (n= 20) groups, respectively. After 2 years, both groups lost BMD at the femoral neck and trochanter (P≤ 0.01), whereas only the WL-M group reduced BMD at the 1/3 radius (P< 0.001). There was greater BMD loss at the trochanter (− 6.8%[5.7%]) and 1/3 radius (− 4.5%[3.3%]) in the WL-M group compared with the WL-R group after 2 years. Multiple linear regression showed that change in leg fat mass (but not trunk fat) contributed to trochanter BMD loss (P< 0.05).ConclusionsAfter 2 years, there is no BMD recovery of weight reduction–induced bone loss, irrespective of weight regain. These data suggest that the period after weight loss may be an important point in time to prevent bone loss for those who maintain weight and those who regain weight.
