Lignans from the heartwood of Streblus asper and their inhibiting activities to Hepatitis B virus
Lignans from the heartwood of Streblus asper and their inhibiting activities to Hepatitis B virus
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Streblus asper心材中的木脂素及其对乙型肝炎病毒的抑制活性
DOI：
10.1016/j.fitote.2011.11.008
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发表时间：
2012-03-01
期刊：
影响因子：
3.4
通讯作者：
Li, Shan
中科院分区：
文献类型：
--
作者：
Li, Lu-Qing;Li, Jun;Li, Shan
从金鱼草（Streblus asper）心材的正丁醇和氯仿萃取物中分离得到3个新的木脂素类化合物：赤型-金鱼草木脂素（1）、苏型-7 '-甲氧基金鱼草木脂素（2）和反式-7'-甲氧基金鱼草木脂素（3），以及12个已知化合物。通过广泛的光谱方法，包括MS和2D NMR实验（HMQC和HMBC），对它们的结构进行了解析。在手性中心的立体化学确定使用CD光谱，以及耦合常数和旋光度数据的分析，分别。初步生物活性测定结果表明，6-羟基-7-甲基香豆素（5）和熊果酸（10）具有抗HBV活性，对HBsAg无细胞毒性时的IC 50值分别为29.60 μ M和89.91 μ M，对HBeAg无细胞毒性时的IC 50值分别为46.41 μ M和97.61 μ M。(C)2011爱思唯尔有限公司版权所有。
Three new lignans, erythro-strebluslignanol (1), threo-7'-methoxyl strebluslignanol (2) and erythro-7'-methoxyl strebluslignanol (3), together with twelve known compounds were isolated from the n-butanol and chloroform fractions of the heartwood of Streblus asper. Their structures were elucidated through extensive spectroscopic methods, including MS and 2D NMR experiments (HMQC and HMBC). The stereochemistry at the chiral center was determined using CD spectra, as well as analysis of coupling constants and optical rotation data, respectively. Primary bioassays showed that 6-hydroxyl-7-methoxyl-coumarin (5) and ursolic acid (10) showed anti-HBV activities, with IC50 values of 29.60 mu M and 89.91 mu M for HBsAg at no cytotoxicity, and IC50 values of 46.41 mu M and 97.61 mu M for HBeAg at no cytotoxicity, respectively. (C) 2011 Elsevier B.V. All rights reserved.