Bone mineral density and respiratory muscle strength in male individuals with mental retardation (with and without Down Syndrome)
Bone mineral density and respiratory muscle strength in male individuals with mental retardation (with and without Down Syndrome)
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DOI：
10.1016/j.ridd.2010.05.003
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发表时间：
2010-11-01
影响因子：
3.1
通讯作者：
Cipriano, Gerson, Jr.
中科院分区：
文献类型：
--
作者：
Maldaner da Silva, Vinicius Zacarias;Barros, Jonatas de Franca;Cipriano, Gerson, Jr.
本研究的目的是评估呼吸肌力量（RMS）在精神发育迟滞（MR）的个人，有或没有唐氏综合征（DS），其与骨密度（BMD）的关系。45名年龄在20-35岁的男性个体（15名DS，15名精神发育迟滞（MR）和15名明显健康的对照）参加了这项研究。受试者评估包括肺功能检查、RMS（最大吸气压，MIP和最大呼气压，MEP）和第二和第四腰椎的BMD。ANOVA用于检验组间差异。当用ANOVA检测到显著差异时，使用Tukey事后检验。用Pearson相关系数计算BMD和呼吸肌强度的双变量相关性。与对照组相比，患有MR的个体，无论有无DS，FEV 1、FVC、MIP和MEP均较低（p < 0.001）。患有DS的个体也具有较低的BMD，这与较低的MIP和MEP相关。肌张力减退、久坐不动的生活方式和肥胖可能是DS患者MIP和MEP较低的原因。增加RMS的策略可以降低DS人群中骨质疏松症的风险。(C)2010爱思唯尔有限公司版权所有。
The purpose of this study was to assess the respiratory muscle strength (RMS) in individuals with mental retardation (MR), with or without Down Syndrome (DS), and its association with bone mineral density (BMD). Forty-five male individuals (15 with DS, 15 with mental retardation (MR) and 15 apparently healthy controls), aged 20-35, participated in this study. Subject assessment included pulmonary function tests, RMS (maximal inspiratory pressure, MIP, and maximal expiratory pressure, MEP) and BMD of the second and fourth lumbar vertebrae. ANOVA was used to test differences amongst groups. Tukey post hoc test was utilized when significant differences were detected with ANOVA. Bivariate correlation for BMD and respiratory muscle strength was calculated with Pearson's coefficient of correlation. Individuals with MR, both with and without DS, have lower FEV1, FVC, MIP and MEP (p < 0.001) compared to controls. Individuals with DS also had lower BMD, which was associated with lower MIP and MEP. Hypotonia, sedentary lifestyle and obesity are factors that may explain lower MIP and MEP in DS. Strategies to increase RMS could decrease the risk of osteoporosis in the DS population. (C) 2010 Elsevier Ltd. All rights reserved.