Disease burden of enterovirus 71 in rural central China: A community-based survey
Disease burden of enterovirus 71 in rural central China: A community-based survey
复制标题
DOI：
10.1080/21645515.2015.1059980
复制
发表时间：
2015-10-03
影响因子：
4.8
通讯作者：
Zhu, Feng-cai
中科院分区：
文献类型：
--
作者：
Gan, Zheng-kai;Jin, Hui;Zhu, Feng-cai
近年来，以亚太地区为中心的手足口病（HFMD）流行具有高发病率和高死亡率的特点。肠病毒71型（EV71）感染是导致手足口病严重病例和死亡的主要原因。这是一项以社区为基础的调查，旨在估计中国中部农村EV71的疾病负担，特别是手足口病。从2011年到2013年，使用结构化问卷收集了343名患病儿童及其父母的人口统计和社会经济数据。我们量化了EV71感染导致的残疾调整生命年（DIMs）疾病的健康负担。在343宗个案中，303宗证实为手足口病，6宗出现疱疹性咽峡炎，25宗出现呼吸道病征，9宗出现非特异性病征。重症病例为47例（包括1例死亡），均患有手足口病。重症手足口病、轻度手足口病、疱疹性咽峡炎、呼吸系统疾病和非特异性疾病的每例患者总成本分别为2149.47美元、513.22美元、53.28美元、31.95美元和39.25美元。EV71相关疾病的总费用占当地农民人均纯收入的比例从非特异性疾病的0.18%到重症手足口病的187.12%不等。每千人因5种疾病而损失的疾病年数分别为3.47、1.76、1.07、1.44、1.22人年。本研究提供了EV71引起的疾病的治疗费用和健康负担数据，可用于EV71疫苗成本效果的评估。
In recent years, the epidemics of hand, foot, and mouth disease (HFMD) centered in the Asian-Pacific region have been characterized by high morbidity and mortality. Enterovirus 71 (EV71) infections were responsible for the majority of the infections leading to severe cases of HFMD and death. This is a community-based survey aimed to estimate the disease burden of EV71 in rural central China, especially for HFMD. From 2011 to 2013, demographic and socio-economic data were gathered from 343 ill children and their parents using a structured questionnaire. We quantified the health burden of disease resulting from EV71 infection in disability-adjusted life years (DALYs). Among 343 cases, 303 had confirmed HFMD, 6 presented with herpangina, 25 presented with respiratory symptoms, and 9 presented with non-specific symptoms. The number of severe cases was 47 (including 1 death) and all of these presented with HFMD. The total cost per patient for severe HFMD, mild HFMD, herpangina, respiratory disease, and non-specific disease was $2149.47, $513.22, $53.28, $31.95, and $39.25, respectively. The overall cost of EV71-related diseases as a proportion of local farmers' per capita net income ranged from 0.18% for those with non-specific disease to 187.12% for those with severe HFMD. The loss of DALYs for the 5 forms of disease were 3.47, 1.76, 1.07, 1.44, 1.22 person-years per 1000 persons, respectively. This study provides data on cost of treatment and health burden for diseases caused by EV71, which can be used in the evaluation of EV71 vaccine cost-effectiveness.