A hypertonic infusion in the treatment of experimental shock in calves and clinical shock in dogs and cats
A hypertonic infusion in the treatment of experimental shock in calves and clinical shock in dogs and cats
复制标题
高渗输注治疗犊牛实验性休克和犬猫临床休克
DOI：
10.1136/vr.133.24.585
复制
发表时间：
1993
影响因子：
2.2
通讯作者：
M. Goddard
中科院分区：
文献类型：
--
作者：
R. Dupe;RJ Bywater;M. Goddard
一种用于静脉注射的新型复合高渗溶液在两个实验模型中进行了测试，一个是内毒素休克，另一个是与脱水相关的休克，两者均在麻醉的小牛中进行。内毒素休克是用大肠杆菌脂多糖诱导的，其特征是低心输出量、低氧血症、酸中毒和无尿。使用少量溶液进行治疗可增加心输出量、改善氧输送、纠正酸中毒并刺激肾功能。犊牛实验性脱水是由腹腔内甘露醇和呋塞米利尿引起的，其特征是循环血浆容量减少、酸中毒和外周灌注不良。使用新溶液的治疗比单独使用高渗或等渗盐水的治疗更能纠正酸中毒并刺激外周循环，并且还增加了犊牛的血浆容量。还在临床小动物实践中将新解决方案与传统液体疗法进行了比较。二十只患有临床休克的猫和狗接受了少量高渗溶液或大量等渗液体的治疗。用少量高渗溶液治疗的动物比用大量等渗液体治疗的动物反应更好。
A novel composite hypertonic solution for intravenous use was tested in two experimental models, one of endotoxic shock and one of shock linked with dehydration, both in anaesthetised calves. Endotoxic shock was induced with Escherichia coli lipopolysaccharide and was characterised by a low cardiac output, hypoxaemia, acidosis and anuria. Treatment with a small volume of the solution increased cardiac output, improved oxygen carriage, corrected acidosis and stimulated renal function. Experimental dehydration in calves was induced by intraperitoneal mannitol and frusemide diuresis, and was characterised by reduced circulating plasma volume, acidosis and poor peripheral perfusion. Treatment with the new solution corrected the acidosis and stimulated peripheral circulation significantly better than treatment with hypertonic or isotonic saline alone, and also expanded the calves' plasma volume. The new solution was also compared with conventional fluid therapy in clinical small animal practice. Twenty cats and dogs with clinical shock were treated with either small volumes of the hypertonic solution or large volumes of isotonic fluids. The animals treated with small volumes of the hypertonic solution responded better than the animals treated with large volumes of isotonic fluid.