MicroRNA patents in demyelinating diseases: a new diagnostic and therapeutic perspective.
MicroRNA patents in demyelinating diseases: a new diagnostic and therapeutic perspective.
复制标题
DOI：
10.2174/187221512799303127
复制
发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
姚忠祥
中科院分区：
文献类型：
--
作者：
姚忠祥
microRNA（miRNAs，miRs）是一类非编码单链RNA，通过miRNA-mRNA相互作用在转录后水平负调控基因表达。研究表明，miRNAs在细胞增殖、分化、凋亡和肿瘤发生等多种生物学过程中发挥重要作用。最近的研究表明，特定的miRNA在控制少突胶质细胞（OL）分化和髓鞘形成中起着至关重要的作用。miRNAs的失调是脱髓鞘疾病发病机制中的重要事件。此外，miRNAs的新专利也为脱髓鞘疾病，特别是多发性硬化症的基因治疗和miR-drug开发提供了新的策略。本文简要介绍miRNAs在OL分化和脱髓鞘疾病发病机制中的作用，重点介绍miRNAs专利在疾病诊断和治疗方面的意义及其相关技术和临床应用面临的挑战。
MicroRNAs (miRNAs, miRs) are a class of non-coding single-stranded RNAs, which can negatively regulate gene expression at posttranscriptional levels by miRNA-mRNA interaction. It has been demonstrated that miRNAs play important roles in a variety of biological process, including cell proliferation, differentiation, apoptosis, and tumorigenesis. Recent studies have shown crucial roles of specific miRNAs in controlling oligodendrocyte (OL) differentiation and myelination. Dysregulation of miRNAs is a vital event in the pathogenesis of demyelinating diseases. Furthermore, new patents of miRNAs also provide new strategies for gene therapy and miR-drug development for demyelinating diseases, especially multiple sclerosis. In this review, we briefly introduce the roles of miRNAs in OL differentiation and in the pathogenesis of demyelinating diseases, with emphasis on the implication of miRNAs patents in disease diagnostic and therapeutic perspective and its related technologies and challenges in clinical application.