T cell activation by lipopeptide antigens
T cell activation by lipopeptide antigens
复制标题
DOI：
10.1126/science.1089353
复制
发表时间：
2004-01-23
期刊：
影响因子：
56.9
通讯作者：
Brenner, MB
中科院分区：
文献类型：
--
作者：
Moody, DB;Young, DC;Brenner, MB
与结合肽的主要组织相容性蛋白不同，CD1蛋白向T细胞展示脂质抗原。在这里，我们报告说，CD1a提出了一个家庭以前未知的脂肽从结核分枝杆菌，命名为双脱羟基分枝杆菌素，因为它们的结构关系，分枝杆菌素铁载体。T细胞活化由α T细胞受体介导，并且对这些抗原的酰基和肽组分的结构具有特异性。这些研究确定了一种细胞内病原体检测的方法，并将脂肽鉴定为T细胞的生化类抗原，其与常规肽一样具有显著结构多样性的潜力。
Unlike major histocompatibility proteins, which bind peptides, CD1 proteins display lipid antigens to T cells. Here, we report that CD1a presents a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. T cell activation was mediated by the alphabeta T cell receptors and was specific for structure of the acyl and peptidic components of these antigens. These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity.