ALCOHOLIC LIVER-DISEASE - QUANTITATIVE IMAGE-GUIDED P-31 MR SPECTROSCOPY
ALCOHOLIC LIVER-DISEASE - QUANTITATIVE IMAGE-GUIDED P-31 MR SPECTROSCOPY
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DOI：
10.1148/radiology.173.2.2798871
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发表时间：
1989-11-01
期刊：
影响因子：
19.7
通讯作者：
WEINER, MW
中科院分区：
文献类型：
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作者：
MEYERHOFF, DJ;BOSKA, MD;WEINER, MW
对酒精性肝炎（n = 10）、酒精性肝硬化（n = 9）和病毒性肝炎B（n = 3）患者以及健康对照组（n = 21）的肝脏进行磷-31磁共振（MR）波谱分析。氢-1 MR图像引导定位技术（ISIS）用于从肝脏内感兴趣的体积中选择性地获取P-31光谱。分析光谱以产生肝磷酸单酯、磷酸二酯、无机磷酸盐和三磷酸腺苷的绝对摩尔浓度。发现（a）酒精性肝病的肝代谢率与健康受试者的肝代谢率无显著差异，（B）与健康受试者相比，酒精性肝炎的绝对肝代谢物浓度降低25%-46%，酒精性肝硬化的绝对肝代谢物浓度降低13%-50%，（c）健康受试者的肝细胞内pH为7.4，酒精性肝硬化的酸性更强，酒精性肝炎的碱性更强研究结果表明，肝脏代谢物的比例是不是一个敏感的酒精性肝病的措施，定量P-31磁共振波谱能够非侵入性地显示与酒精性肝病相关的代谢变化，酒精性肝炎和肝硬化可以区分通过肝细胞内pH值测量与磁共振波谱。
Phosphorus-31 magnetic resonance (MR) spectroscopy was performed on the liver of patients with alcoholic hepatitis (n = 10), alcoholic cirrhosis (n = 9), and viral hepatitis B(n = 3) and on healthy control subjects (n = 21). A hydrogen-1 MR image-guided localization technique (ISIS) was used to acquire P-31 spectra selectively from a volume of interest within the liver. Spectra were analyzed to yield absolute molar concentrations of hepatic phosphomonoesters, phosphodiesters, inorganic phosphate, and adenosine triphosphate. It was found that (a) hepatic metabolic ratios in alcoholic liver disease were not significantly different from those in healthy subjects, (b) absolute hepatic metabolite concentrations were decreased by 25%-46% in alcoholic hepatitis and 13%-50% in alcoholic cirrhosis compared with those in healthy subjects, and (c) hepatic intracellular pH was 7.4 in healthy subjects, more acidic in alcoholic cirrhosis, and more alkaline in alcoholic hepatitis. The findings indicate that hepatic metabolite ratios are not a sensitive measure of alcoholic liver disease, that quantitative P-31 MR spectroscopy is able to noninvasively show metabolic changes associated with alcoholic liver disease, and that alcoholic hepatitis and cirrhosis may be distinguished by means of hepatic intracellular pH measured with MR spectroscopy.