Comparative Activity of Proline-Containing Dipeptide Noopept and Inhibitor of Dipeptidyl Peptidase-4 Sitagliptin in a Rat Model of Developing Diabetes
Comparative Activity of Proline-Containing Dipeptide Noopept and Inhibitor of Dipeptidyl Peptidase-4 Sitagliptin in a Rat Model of Developing Diabetes
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含脯氨酸二肽 Noopept 和二肽基肽酶 4 抑制剂西格列汀在糖尿病大鼠模型中的活性比较
DOI：
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发表时间：
2014
影响因子：
0.7
通讯作者：
S. Seredenin
中科院分区：
文献类型：
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作者：
R. Ostrovskaya;I. Ozerova;T. A. Gudascheva;I. Kapitsa;E. Ivanova;T. Voronina;S. Seredenin
成年雄性Wistar大鼠以30 mg/kg亚糖尿病剂量连续3d多次腹腔注射链脲佐菌素复制糖尿病模型。在每次注射毒素前，口服含脯氨酸二肽类药物诺培特或糖尿病标准药物二肽基肽酶-4抑制剂西格列汀，剂量为5 mg/kg，链脲佐菌素疗程结束后连续16天。主动对照组在第三次注射毒素后第二天自发升高血糖水平，降低对葡萄糖负荷(1000 mg/kg)的耐受量。基础血糖水平在第16天下降，但糖耐量仍受损。诺培特使链脲佐菌素治疗后第二天的基础血糖水平和糖负荷耐量恢复正常。诺贝特的作用一直持续到实验结束。在实验的早期阶段，西格列汀对基础血糖水平的影响略优于诺培特，但对糖耐量的影响不如诺贝特。实验结束时，诺贝特对糖耐量的影响显著超过西格列汀(2倍)。
Developing diabetes was modeled on adult male Wistar rats by repeated intraperitoneal injections of streptozotocin in a subdiabetogenic dose of 30 mg/kg for 3 days. Proline-containing dipeptide drug Noopept or a standard diabetic drug dipeptidyl peptidase-4 inhibitor sitagliptin was administered per os in a dose of 5 mg/kg before each injection of the toxin and then for 16 days after streptozotocin course. In active control group, spontaneously increase glucose level and reduced tolerance to glucose load (1000 mg/kg intraperitoneally) were observed on the next day after the third administration of toxin. Basal glucose level decreased by day 16, but glucose tolerance remained impaired. Noopept normalized the basal blood glucose level and tolerance to glucose load on the next day after administration of streptozotocin. The effect of Noopept persisted to the end of the experiment. At early terms of the experiment, sitagliptin was somewhat superior to Noopept by the effect on baseline glucose level, but was inferior by the influence on glucose tolerance.. By the end of the experiment, Noopept significantly (by 2 times) surpassed sitagliptin by its effect on glucose tolerance.
影响因子：
4
作者：
Fonseca, Sonya G.;Burcin, Mark;Gromada, Jesper;Urano, Fumihiko
通讯作者：
Urano, Fumihiko