Modeling on the Three-Dimensional Printing of Human Organs
Modeling on the Three-Dimensional Printing of Human Organs
复制标题
人体器官三维打印建模
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
J. Silva
中科院分区：
文献类型：
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作者：
R. Rezende;V. Mironov;J. Silva
这项工作展示了信息技术如何应用于生物制造，特别是展示了计算建模和仿真。器官打印是一种新兴的无实体支架生物制造技术，或逐层添加生物打印功能的3D人体组织和自组装组织球体构建的器官结构。器官打印是组织工程的一种替代方法。受损和患病的器官可以被3D打印机制造的新器官所取代。生物制造周期过于复杂。一开始，输入由医学图像或器官设计提供。在中间阶段，蓝图和生物打印进一步进行器官成熟的生物反应器。最后是临床阶段。为了获得最终的3D生物打印器官，必须完成完整的生物制造周期。所有这些阶段都与信息技术（IT）有关，因为图像处理、计算模拟、通过虚拟模型的器官表示都直接涉及到。此时，重点是成熟阶段。通过数学建模和计算机仿真，估计了合适的设计参数和成熟情景。在3D打印人体器官之后，这需要在生物反应器中成熟，以便植入。生物反应器通过控制其机械、生化和电条件来加速组织成熟，保持工程组织的活力。这项工作提出了一项初步研究，该研究再现了生物反应器方法中包含的元素，并在基于Ansys CFX软件上运行的有限元方法的模拟中考虑了一些变量。
This work demonstrates how information technology can be employed onto biofabrication, specifically showing a computational modeling and simulation. Organ printing is an emerging solid scaffold-free biofabrication technology or layer by layer additive bioprinting of functional 3D human tissue and organ constructs from self-assembling tissue spheroids. Organ printing comes as an alternative way to the tissue engineering. Damaged and diseased organs could be replaced by the new organ fabricated by a 3D printer. The biofabrication cycle is too complex. On the beginning, the input is feed by medical images or an organ design. At an intermediary level, the blueprint and bioprinting further the bioreactor for the organ maturation take place. At the end, the clinical phase. In order to have a final 3D bioprinted organ, the complete biofabrication cycle has to be accomplished. All of these phases are associated to the information technology (IT) since image treatments, computational simulations, organ representation through a virtual model are straightly involved. At this moment, the focus is on the maturation phase. Mathematical modeling and computer simulation have been used to estimate proper design parameters and maturation scenario. After 3D printing the human organ, this needs to be matured in a bioreactor in order to be implantable. Bioreactors are used to accelerate tissue maturation through the control of their mechanical, biochemical and electrical conditions maintaining the viability of the engineered tissue. This work presents an incipient study that reproduces elements included in the bioreactor approach with some variables considered at the simulations based on the finite element method running on Ansys CFX software.