Colorectal Counterpart of Gastric Depressed Adenoma: A Comparison with Flat and Polypoid Adenomas with Special Reference to the Development of Pericryptal Fibroblasts
Colorectal Counterpart of Gastric Depressed Adenoma: A Comparison with Flat and Polypoid Adenomas with Special Reference to the Development of Pericryptal Fibroblasts
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胃凹陷性腺瘤的结直肠对应物：与扁平腺瘤和息肉状腺瘤的比较，特别参考隐窝周围成纤维细胞的发育
DOI：
10.1097/00000478-199406000-00002
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
M. Tsuneyoshi
中科院分区：
文献类型：
--
作者：
T. Yao;S. Tada;M. Tsuneyoshi
采用肌特异性肌动蛋白（HHF-35）免疫组化染色，对28例凹陷性腺瘤（DA）、40例无中央凹陷的扁平腺瘤（FA）和29例息肉样腺瘤（PA）的组织学特征进行了比较，特别是对隐窝周围成纤维细胞（PCF）的发育进行了研究。DA由直径小于PA的腺瘤性小管的拥挤集合组成。关于PCF的发育，DA的PCF发育不良; PCF（-）、（+）和（+ +）分别为12（43%）、16（57%）和0（0%）。另一方面，非凹陷性腺瘤（PA和FA）具有发育良好的PCF; PCF（-）、（+）和（++）分别为5（7%）、35（51%）和29（42%）。此外，PCF的数量似乎减少的顺序PA，其次是FA和DA。根据我们的研究结果，DA具有特征性的组织学结构以及发育不良的PCF特征，这将它们与PA区分开来。因此，凹陷型腺瘤被认为是扁平型腺瘤的一个亚型。PCFs的缺失似乎与腺瘤的生长抑制有关。
The histological features of 28 depressed adenomas (DAs) were compared with those of 40 flat adenomas (FAs) without a central depression and those of 29 polypoid adenomas (PAs), with special reference to the development of pericryptal fibroblasts (PCFs), using immunohistochemical staining for muscle-specific actin (HHF-35). The DAs were composed of a crowded collection of adenomatous tubules with smaller diameters than those of the PAs. With regard to PCF development, the DAs had poorly developed PCFs; PCF (-),(+), and (+ +) numbered 12 (43%), 16 (57%), and 0 (0%), respectively. On the other hand, the nondepressed adenomas (PAs and FAs) had well-developed PCF; PCF (-),(+), and (++) numbered 5 (7%), 35 (51%), and 29 (42%), respectively. In addition, the number of PCFs seemed to decrease in the sequence of PAs, followed by FAs and DAs. According to our results, the DAs had a characteristic histological architecture together with poorly developed PCFs features, which distinguished them from the PAs. In conclusion, the depressed adenomas were considered a subtype of the flat adenomas. The depletion of PCFs seems to correlate with the depressed growth of the adenoma.