Triclosan: Applications and safety
Triclosan: Applications and safety
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DOI：
10.1016/s0196-6553(96)90017-6
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发表时间：
1996-06-01
影响因子：
4.9
通讯作者：
Leonard, PA
中科院分区：
文献类型：
--
作者：
Bhargava, HN;Leonard, PA
三氯生(2，4，4‘-三氯-2’-羟基二苯醚)是一种非离子、广谱抗菌剂，由于其良好的安全性，已被用于多种个人护理产品，包括除臭皂、腋下除臭剂、沐浴露和医护人员洗手液。三氯生对皮肤表现出中等程度的实体作用，在许多产品中，它具有残留的抗菌效果。尽管在过度暴露的条件下直接接触这种物质会对实验动物产生皮肤刺激，但在配方产品中很少与人类的皮肤刺激或致敏有关。急性、亚急性/亚慢性。已经建立了慢性毒性图谱，以确定三氯生既不是急性口服毒物，也不是致癌物、诱变剂或致畸剂。三氯生的一个新应用是用于口腔牙膏的菌斑控制。目前在美国接受调查，它在加拿大和许多欧洲国家被批准用于口腔护理。
Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is a nonionic, broad spectrum, antimicrobial agent that, because of its favorable safety profile, has been incorporated into a variety of many personal care products, including deodorant soaps, underarm deodorants, shower gels, and health care personnel handwashes. Triclosan exhibits a moderate degree of substantivity to the skin, and, in many products, it imparts a remnant antimicrobial effect. Although direct contact with the material under exaggerated exposure conditions causes dermal irritation in laboratory animals, it has only rarely been associated with skin irritation or sensitization in human beings in formulated products. Acute, subacute/subchronic. and chronic toxicity profiles have been established to determine that triclosan is neither an acute oral toxicant nor that it acts as a carcinogen, mutagen, or teratogen. A new application for triclosan is in oral dentifrices for plaque control. Currently under investigation in the United States, it is approved for oral care application in Canada and many European countries.