Distribution of astrocytic plaques in the corticobasal degeneration brain and comparison with tuft-shaped astrocytes in the progressive supranuclear palsy brain
Distribution of astrocytic plaques in the corticobasal degeneration brain and comparison with tuft-shaped astrocytes in the progressive supranuclear palsy brain
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DOI：
10.1007/s00401-003-0711-4
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发表时间：
2003-08-01
影响因子：
12.7
通讯作者：
Ojika, K
中科院分区：
文献类型：
--
作者：
Hattori, M;Hashizume, Y;Ojika, K
皮质基底节变性（CBD）和进行性核上性麻痹（PSP）有一些共同的临床和病理特征。然而，每一种都有特定的星形胶质细胞内含物。CBD以星形胶质细胞斑块为特征，PSP以簇状星形胶质细胞为特征。为了阐明这些夹杂物之间的差异，我们研究了CBD或PSP患者尸检大脑中星形胶质细胞斑块和簇状星形胶质细胞的脑内分布。采用Gallyas-Braak法对10例CBD患者和5例PSP患者的标本进行染色。对11个大脑皮质区、6个皮质下核、5个脑干区、小脑皮质和齿状核的星形胶质细胞斑块和簇状星形胶质细胞的密度进行了测定。星形胶质细胞斑块在CBD大脑皮层的前额和运动前区最丰富，而簇状星形胶质细胞在PSP大脑的中央前回和运动前区最突出。CBD脑尾状核中观察到许多星形胶质细胞斑块，而PSP脑尾状核和壳核中的簇状星形胶质细胞丰富，苍白球、丘脑底核和丘脑中的数量适中。在CBD脑的脑干中观察到非常轻微的星形胶质细胞斑块积聚，而在PSP脑的红核和上级丘中发现大量簇状星形胶质细胞。星形胶质细胞斑块和簇状星形胶质细胞的分布差异很大。因此，CBD和PSP可以被视为不同的实体。
Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) have some clinical and pathological features in common. Each, however, has been shown to have specific astrocytic inclusions. CBD is characterized by astrocytic plaques, and PSP is characterized by tuft-shaped astrocytes. To clarify differences between these inclusions, we investigated intracerebral distribution of astrocytic plaques and tuft-shaped astrocytes in autopsied brains of patients with either CBD or PSP. Specimens from ten patients with CBD and five patients with PSP were stained by the Gallyas-Braak method. Densities of the astrocytic plaques and tuft-shaped astrocytes were determined for 11 cerebral cortical regions, 6 subcortical nuclei, 5 brain stem regions, the cerebellar cortex and the dentate nucleus. Astrocytic plaques were most abundant in the prefrontal and premotor areas in the cerebral cortex of CBD brains, whereas tuft-shaped astrocytes were most prominent in the precentral gyrus and premotor area of PSP brains. Many astrocytic plaques were observed in the caudate nucleus of CBD brains, whereas tuft-shaped astrocytes were abundant in both the caudate and putamen and moderate in number in the globus pallidus, subthalamic nucleus and thalamus in PSP brains. Very slight accumulation of astrocytic plaques was seen in the brain stem of CBD brains, whereas numerous tuft-shaped astrocytes were found in the red nucleus and superior colliculus of PSP brains. Distribution of the astrocytic plaques and tuft-shaped astrocytes differed greatly. Thus, CBD and PSP can be considered different entities.