NEW SERUM INDICATOR OF INTERSTITIAL PNEUMONITIS ACTIVITY - SIALYLATED CARBOHYDRATE ANTIGEN KL-6
NEW SERUM INDICATOR OF INTERSTITIAL PNEUMONITIS ACTIVITY - SIALYLATED CARBOHYDRATE ANTIGEN KL-6
复制标题
DOI：
10.1378/chest.96.1.68
复制
发表时间：
1989-07-01
期刊：
影响因子：
9.6
通讯作者：
AKIYAMA, M
中科院分区：
文献类型：
--
作者：
KOHNO, N;KYOIZUMI, S;AKIYAMA, M
通过使用抗唾液酸化碳水化合物抗原的单克隆抗体KL-6的夹心试验检测高分子量循环抗原KL-6的血清水平，评价其在监测间质性肺炎活动中的有用性。在59例间质性肺炎患者中，34例（58%）的血清中观察到KL-6抗原水平异常高。血清KL-6抗原与LDH活性无明显相关性。KL-6抗原水平与67 Ga-柠檬酸盐荧光图测量的临床疾病活动程度和临床病程呈正相关。虽然这是一项初步研究，但这些观察结果表明，血清KL-6抗原水平可能是间质性肺炎患者疾病活动性的有用指标。然而，在间质性肺炎与恶性和非恶性疾病的鉴别诊断中，它似乎没有用。
Serum levels of a high molecular weight circulating antigen KL-6, detected by means of a sandwich assay using a monoclonal antibody KL-6 against a sialylated carbohydrate antigen, were evaluated for usefulness in monitoring the activity of interstitial pneumonitis. Abnormally high levels of KL-6 antigen were observed in the sera of 34 (58 percent) of 59 patients with interstitial pneumonitis. There was no significant correlation between serum values of KL-6 antigen and LDH activity. There was a positive correlation between KL-6 antigen levels and the degree of clinical disease activity as measured by 67Ga-citrate scintigram and the clinical course. Though this is a preliminary study, these observations suggest that the serum level of KL-6 antigen may be a useful indicator of disease activity in patients with interstitial pneumonitis. It does not appear to be useful, however, in the differential diagnosis of interstitial pneumonitis from malignant and nonmalignant diseases.