A10 dopamine neurons: role of autoreceptors in determining firing rate and sensitivity to dopamine agonists.
A10 dopamine neurons: role of autoreceptors in determining firing rate and sensitivity to dopamine agonists.
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A10 多巴胺神经元：自身受体在确定放电率和对多巴胺激动剂敏感性中的作用。
DOI：
10.1016/0024-3205(84)90088-2
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发表时间：
1984
期刊：
影响因子：
6.1
通讯作者：
Wang,RY
中科院分区：
文献类型：
--
作者：
White,FJ;Wang,RY
本实验研究了A10多巴胺（DA）神经元自发放电频率与其对阿扑吗啡（APO）、右旋苯丙胺（AMP）及微电泳DA抑制剂的敏感性之间的关系。结果表明，DA神经元自发放电频率与其对DA及DA激动剂的敏感性之间存在显著的负相关关系，即A10 DA神经元的自发速率越快，该细胞对激动剂诱导的抑制越不敏感。这种关系没有发现离子电渗γ-氨基丁酸的速率抑制作用。有没有显着差异的影响，离子电渗DA前谷氨酸和谷氨酸驱动的活动相同的A10 DA神经元，更快的放电率，本身，并没有决定这些细胞的敏感性DA激动剂。相反，这些结果表明，自发活动和DA受体激动剂的敏感性可能是由密度（或敏感性）的DA自身受体A10 DA神经元。这一假设得到了以下发现的支持：逆行识别的中皮层DA神经元，其对DA、APO和AMP的反应显著较低，表现出比其他A10 DA神经元显著更快的放电速率。因此，A10 DA神经元的这个亚群主要由具有低自身受体密度（或敏感性）的细胞组成。
The present experiments investigated the relationship between the spontaneous basal firing rate of A10 dopamine (DA) neurons and their sensitivity to the rate-suppressant effects of intravenously administered apomorphine (APO) and d-amphetamine (AMP) as well as microiontophoretically ejected DA. The results indicated highly significant inverse relationships between basal neuronal activity and sensitivity to DA and DA agonists, ie the faster the spontaneous rate of an A10 DA neuron, the less sensitive that cell was to agonist-induced suppression. This relationship was not found for the rate suppressant effects of iontophoretic gamma-aminobutyric acid. There were no significant differences between the effects of iontophoretic DA on pre-glutamate and glutamate-driven activity of the same A10 DA neurons indicating that faster firing rates, per se, did not determine the sensitivity of these cells to DA agonists. Rather, these results suggest that both spontaneous activity and sensitivity to DA agonists may be determined by the density (or sensitivity) of DA autoreceptors on A10 DA neurons. This hypothesis was supported by the finding that antidromically identified mesocortical DA neurons, which were significantly less responsive to DA, APO and AMP exhibited significantly faster firing rates than other A10 DA neurons. Thus, this subpopulation of A10 DA neurons is primarily made up of cells with low autoreceptor density (or sensitivity).