The Molecular Theory of Radiation Biology
The Molecular Theory of Radiation Biology
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放射生物学的分子理论
DOI：
10.1080/09553008214551391
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发表时间：
1982
影响因子：
2.6
通讯作者：
O. Scott
中科院分区：
文献类型：
--
作者：
O. Scott
大多数研究报告本身比研讨会的日期要及时得多很明显，作者们能够在会议结束几个月后写出最后的草稿出版。这对读者来说当然是一个优势。研究报告几乎完全涉及疾病的细胞和/或亚细胞方面。报告的研究包括：各种DNA损伤剂治疗后的存活率、电离辐射和化学品暴露后的碱基损伤修复、单链和双链断裂的诱导和修复、电离辐射暴露后对DNA合成速率的影响以及电离辐射诱导的突变。杂合子是否是放射敏感的，他们是否易患癌症的问题进行了讨论的结论，杂合子确实在这两种情况下的风险。一个领域，将造成相当大的混乱，以读者是有缺陷的DNA修复的作用，在病因的疾病。那些报道共济失调-毛细血管扩张症其他方面的人显然也对这个问题感到困惑，阅读本书中关于这个主题的所有研究论文对缓解这种情况没有什么帮助。不幸的是，这种混乱准确地反映了该领域的现状，对这个问题感兴趣的人有必要跟上文献，看看它是如何解决的。这本书很好地反映了该领域的现状。它不仅是一个有价值的和方便的手段，为那些目前没有工作的共济失调毛细血管扩张症，以评估目前的研究状况，在该领域，但也为那些积极在一个领域，它欣赏目前的研究在其他领域。
Most of the research reports themselves are much more up to date than the workshop dates would suggest-obviously the authors were able to write the final drafts for publication some months after the meeting. This is of course an advantage to the reader. The research reports deal almost exclusively with cellular and/or subcellular aspects of the disease. Studies reported include: survival after treatment with various DNA-damaging agents, base-damage repair after exposure to ionizing radiation and to chemicals, induction and repair of single-and double-strand breaks, effects on the rate of DNA synthesis after exposure to ionizing radiation, and mutation induction by ionizing radiation. The questions of whether heterozygotes are radiosensitive and whether they are predisposed to cancer are discussed with the conclusion that heterozygotes are indeed at risk in both cases. One area that will cause considerable confusion to the reader is the role of defective DNA repair in the etiology of the disease. Those reporting on other aspects of ataxia-telangiectasia are also obviously confused about this issue and the reading of all of the research papers on the subject in this book does little to alleviate the situation. Unfortunately this confusion accurately reflects the current situation in the field and it will be necessary for those interested in this problem to keep abreast of the literature to see how it is resolved. The book is an excellent reflection of the current status of the field. Not only is it a valuable and convenient means for those not presently working on ataxia-telangiectasia to assess the present status of research in the field but also for those active in one area of it to appreciate the current research in other areas.