Public Attitudes toward Gene Therapy in China.
Public Attitudes toward Gene Therapy in China.
复制标题
中国公众对基因治疗的态度
DOI：
10.1016/j.omtm.2017.05.008
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发表时间：
2017-09-15
期刊：
影响因子：
--
通讯作者：
He Y
中科院分区：
文献类型：
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作者：
Wang JH;Wang R;Lee JH;Iao TWU;Hu X;Wang YM;Tu LL;Mou Y;Zhu WL;He AY;Zhu SY;Cao D;Yang L;Tan XB;Zhang Q;Liang GL;Tang SM;Zhou YD;Feng LJ;Zhan LJ;Tian NN;Tang MJ;Yang YP;Riaz M;van Wijngaarden P;Dusting GJ;Liu GS;He Y
基因治疗是一种将遗传物质输送到人体内以潜在地预防或治疗遗传根源疾病的医疗程序，长期以来一直吸引着科学家，临床医生和公众。尽管基因治疗的历史曲折，在早期试验中出现了几起突出的不良事件，但过去二十年来安全性和有效性的显著改善使该技术重新回到了医学研究的中心舞台。随着基因治疗迅速发展到广泛的临床应用，有越来越多的证据表明，在科学界和公众的关注和怀疑。1在一系列关于基因治疗的问题中，平衡基因治疗的益处和风险是一个反复出现的主题。关于将基因治疗用于非医学目的的伦理辩论，如遗传增强智力或物理美学，一直很激烈。此外，基因治疗对人类生殖细胞的伦理影响也一再引起关注。过去已经进行了许多关于公众对基因治疗或基因编辑态度的研究;然而，这些研究在方法和调查人群的人口统计学和地理属性方面存在很大差异。值得注意的是，这些研究大多数是在西方国家进行的。鉴于中国是世界上人口最多的国家，基因治疗研究能力迅速扩大，了解中国公众和临床医生对基因治疗应用的态度至关重要。
Gene therapy, a medical procedure that delivers genetic materials into a person to potentially prevent or treat disease at its genetic roots, has long fascinated scientists, clinicians, and the general public. Although gene therapy has a checkered history, with several prominent adverse events in early trials, significant safety and efficacy improvements in the last two decades have catapulted the technology back to the center stage of medical research. As gene therapy rapidly progresses toward widespread clinical use, there is growing evidence of concern and skepticism in the scientific community and the general public alike. 1 Among a range of concerns about gene therapy, balancing the benefits and risks of gene therapy stands out as a recurring theme. Ethical debate over the use of gene therapy for non-medical purposes, such as genetic enhancement of intelligence or physical aesthetics, has been robust. In addition, recurrent concerns have been raised about the ethical implications of gene therapy on human germlines.Numerous studies of public attitudes to gene therapy or gene editing have been carried out in the past; however, these studies differ widely in their methods and the demographic and geographic attributes of the populations surveyed. 1, 2 Of note, most of these studies have been conducted in Western countries. Given that China is the most populous nation in the world and has rapidly expanding capacity in gene therapy research, it is of utmost importance to understand the attitudes of the Chinese public and clinicians in relation to the application of gene therapy.