CEREBROVASCULAR LESIONS IN INFANTS AND CHILDREN DYING AFTER EXTRACORPOREAL MEMBRANE-OXYGENATION
CEREBROVASCULAR LESIONS IN INFANTS AND CHILDREN DYING AFTER EXTRACORPOREAL MEMBRANE-OXYGENATION
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DOI：
10.1016/0887-8994(94)90061-2
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发表时间：
1994-02-01
影响因子：
3.8
通讯作者：
AHDABBARMADA, M
中科院分区：
文献类型：
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作者：
JARJOUR, IT;AHDABBARMADA, M
对匹兹堡儿童医院一组在体外膜肺氧合（ECMO）治疗后死亡的婴儿和儿童的神经病理尸检结果进行了审查并制成表格。这项研究调查了一个为期两年的时期（1980年2月至1991年5月），268名儿童接受ECMO治疗的严重心肺功能衰竭，94名患者死亡，其中70人进行了尸检，只有44人获准进行脑部检查。缺血性神经元坏死（50%），局灶性脑梗死（50%），脑内血肿（52%），脑室周围白质软化（41%）的发生率在这组ECMO治疗的患者中高于在一般尸检人群中观察到的研究患者。缺血性和出血性脑损伤的发生率在新生儿、大龄婴儿和儿童中相似。ECMO后死亡的儿童脑血管病变的记录可以更好地了解在这种侵入性手术中存活的更大人群的婴儿和儿童的潜在脑损伤。
The neuropathologic autopsy findings of a group of infants and children at Children's Hospital of Pittsburgh who died after treatment with extracorporeal membrane oxygenation (ECMO) were reviewed and tabulated. The study surveyed an ii-year period (February, 1980 to May, 1991); of 268 children receiving ECMO therapy for severe cardiopulmonary failure, 94 patients died, 70 of whom were autopsied and permission for brain examination was granted in only 44. The frequency of ischemic neuronal necrosis (50%), focal cerebral infarcts (50%), intracerebral hemorrhages (52%), and periventricular leukomalacia (41%) was higher in this group of ECMO-treated patients than that observed in the general autopsy population from which the study patients were selected. The frequency of ischemic and hemorrhagic brain lesions was similar among neonates and older infants and children. This documentation of cerebrovascular lesions in children dying after ECMO may provide a better understanding of potential brain damage in the larger population of infants and children who survive this invasive procedure.