Mediterranean Diet and White Matter Hyperintensity Volume in the Northern Manhattan Study
Mediterranean Diet and White Matter Hyperintensity Volume in the Northern Manhattan Study
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DOI：
10.1001/archneurol.2011.548
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发表时间：
2012-02-01
影响因子：
--
通讯作者：
Wright, Clinton B.
中科院分区：
文献类型：
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作者：
Gardener, Hannah;Scarmeas, Nikolaos;Wright, Clinton B.
目的：研究地中海式饮食（MeDi）和脑磁共振成像白色高信号体积（WMHV）之间的关联。设计：一项纵向人群队列研究中的横断面分析。进行半定量食物频率问卷调查，背景：北方曼哈顿研究。参与者：共有1091名参与者，其中966人有饮食信息（平均年龄72岁; 59.3%为女性，64.6%为西班牙裔，15.6%为白色，17.5%为黑人）。建立线性回归模型，以检查之间的关联的MeDi评分和对数转换的WMHV作为总颅容积的比例，控制社会人口和血管的危险factors.Results：在MeDi量表，11.6%得分0至2，15.8%得分3，23.0%得分4，23.5%得分5，和26.1%得分6至9。MeDi评分每增加1分与较低的logWMHV相关（β =-.04，P=.01）。作为WMHV独立预测因子的唯一MeDi评分成分是单不饱和脂肪与饱和脂肪的比值（β =-0.20，P=.001）。结论：MeDi与较低的WMHV负荷相关，这是脑内小血管损伤的标志。然而，白色高信号在病因上是异质的，可以包括神经变性。需要通过其他基于人群的研究进行复制。
Objective: To examine the association between a Mediterranean-style diet (MeDi) and brain magnetic resonance imaging white matter hyperintensity volume (WMHV).Design: A cross-sectional analysis within a longitudinal population-based cohort study. A semiquantitative food frequency questionnaire was administered, and a score (range, 0-9) was calculated to reflect increasing similarity to the MeDi pattern.Setting: The Northern Manhattan Study.Participants: A total of 1091 participants, of whom 966 had dietary information (mean age, 72 years; 59.3% women, 64.6% Hispanic, 15.6% white, and 17.5% black).Main Outcome Measures: The WMHV was measured by quantitative brain magnetic resonance imaging. Linear regression models were constructed to examine the association between the MeDi score and the log-transformed WMHV as a proportion of total cranial volume, controlling for sociodemographic and vascular risk factors.Results: On the MeDi scale, 11.6% scored 0 to 2, 15.8% scored 3, 23.0% scored 4, 23.5% scored 5, and 26.1% scored 6 to 9. Each 1-point increase in MeDi score was associated with a lower logWMHV(beta=-.04, P=.01). The only MeDi score component that was an independent predictor of WMHV was the ratio of monounsaturated to saturated fat (beta=-.20, P=.001).Conclusions: A MeDi was associated with a lower WMHV burden, a marker of small vessel damage in the brain. However, white matter hyperintensities are etiologically heterogenous and can include neurodegeneration. Replication by other population-based studies is needed.