When do social inequalities in C-reactive protein start?: A life course perspective from conception to adulthood in the Cardiovascular Risk in Young Finns Study
When do social inequalities in C-reactive protein start?: A life course perspective from conception to adulthood in the Cardiovascular Risk in Young Finns Study
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DOI：
10.1093/ije/dym244
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发表时间：
2008-04-01
影响因子：
7.7
通讯作者：
Kivimaki, M.
中科院分区：
文献类型：
--
作者：
Gimeno, D.;Ferrie, J. E.;Kivimaki, M.
背景 目前尚不清楚在生命历程中何时出现炎症方面的社会不平等。我们对青年芬兰人心血管风险研究中的 1484 名参与者进行了调查，研究了社会经济地位 (SEP) 和 C 反应蛋白 (CRP) 之间的关联是否在受孕时、儿童期、青春期或成年期确定。方法使用 CRP 基因的五种变体来研究 CRP 水平的 SEP 差异是否在受孕时确定。在儿童期（39 岁）、青春期（1218 岁）和成年期（2439 岁）评估 SEP 和血清 CRP。 SEP 是通过儿童和青少年时期的父母教育和职业地位以及参与者自己的成年时期教育和职业地位来衡量的。 CRP 10 mg/l 的参与者被排除。结果 所有 CRP 基因变异都与儿童时期循环 CRP 浓度相关，但这些变异在 SEP 上的分布没有差异。没有发现强有力的证据表明父母 SEP 和 CRP 之间存在关联。在成年期观察到，较高的 SEP 和较低的 CRP 之间存在分级关联，与教育有关（P = 0.0005），但与职业地位无关。导致参与者及其父母获得高教育成就的轨迹与较低的教育成就相关（P
Background It is unclear when in the life course do social inequalities in inflammation emerge. We examined whether the association between socioeconomic position (SEP) and C-reactive protein (CRP) is determined at conception, in childhood, adolescence or adulthood in 1484 participants from the population-based Cardiovascular Risk in Young Finns Study.Methods Five variants of the CRP gene were used to investigate whether SEP differences in CRP levels are determined at conception. SEP and serum CRP were assessed in childhood (age 39), adolescence (age 1218) and in adulthood (age 2439). SEP was measured using parental education and occupational status in childhood and adolescence, and participants own education and occupational status in adulthood. Participants with CRP 10 mg/l were excluded.Results All CRP gene variants were associated with circulating CRP concentrations in childhood, but there were no differences in the distribution of these variants by SEP. No strong evidence was found of associations between parental SEP and CRP. A graded association between higher SEP and lower CRP was observed in adulthood for education (P = 0.0005) but not for occupational status. Trajectories that led to high educational achievement both in the participants and their parents were associated with lower (P