Titanocene-based method for indole synthesis
Titanocene-based method for indole synthesis
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DOI：
10.1021/ja972281p
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发表时间：
1998-04-08
影响因子：
15
通讯作者：
Buchwald, SL
中科院分区：
文献类型：
--
作者：
Aoki, K;Peat, AJ;Buchwald, SL
本文介绍了一种新的合成吲哚类化合物的方法，该方法采用了对空气和水分稳定的试剂Cp_2TiCl_2。其关键步骤是（1）烯烃和茂钛稳定的苯炔配合物的分子间插入反应和（2）Pd催化的芳基胺化反应。所需起始原料的简单性和可用性使该方法具有制备多取代吲哚的广泛范围。
A new approach for the construction of indoles employing the air-and moisture-stable reagent Cp2TiCl2 is described. The key steps involved are (1) the intermolecular insertion reactions of an olefin and a titanocene-stabilized benzyne complex and (2) the Pd-catalyzed aryl amination reaction. The simplicity and availability of the requisite starting materials give the method a broad scope for the preparation of polysubstituted indoles.