Persistent shedding of West Nile virus in urine of experimentally infected hamsters
Persistent shedding of West Nile virus in urine of experimentally infected hamsters
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DOI：
10.4269/ajtmh.2005.72.320
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发表时间：
2005-03-01
影响因子：
3.3
通讯作者：
Tesh, RB
中科院分区：
文献类型：
--
作者：
Tonry, JH;Xiao, SY;Tesh, RB
在实验性西尼罗病毒（WNV）感染中存活的成年仓鼠出现了持续性病毒。传染性西尼罗河病毒可以从他们的尿液中培养长达52天。肾免疫组化检查显示肾小管上皮细胞和血管内皮细胞有西尼罗河病毒抗原灶。这些发现与病毒复制和肾上皮细胞的持续感染相一致。这些发现的潜在临床和病毒学意义及其可能的表皮学意义进行了讨论。
Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidermologic importance are discussed.