Elevated red cell distribution width in the diagnosis of thrombotic thrombocytopenic purpura in patients presenting with anemia and thrombocytopenia
Elevated red cell distribution width in the diagnosis of thrombotic thrombocytopenic purpura in patients presenting with anemia and thrombocytopenia
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DOI：
10.1097/01.smj.0000257403.04625.36
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发表时间：
2007-03-01
影响因子：
1.1
通讯作者：
Braverman, Albert
中科院分区：
文献类型：
--
作者：
Nagajothi, Nagaprasad;Braverman, Albert
目的：探讨血栓性血小板减少性紫癜(TTP)患者红细胞分布宽度(RDW)是否升高，并评价RDW升高在TTP诊断中的敏感性和特异性。方法：回顾分析1997~2005年我科收治的25例初诊TTP患者入院时红细胞分布宽度。结果：TTP患者的RDW显著高于对照组(23.1%比17.2%，P=0.000 1)。RDW>；18%诊断TTP的敏感性为95%，特异性为70%，而RDW>；19%的敏感性为80%，特异性为85%。结论：RDW>；=18%的不明原因贫血和血小板减少的患者应怀疑TTP。
Objective: To determine if red cell distribution width (RDW) is elevated in thrombotic thrombocytopenic purpura (TTP) and to evaluate the sensitivity and specificity of such elevation in the diagnosis of TTP.Methods: We retrospectively studied red cell distribution width at presentation in 25 consecutive patients with newly diagnosed TTP who were treated with plasmapheresis in our institution between 1997 to 2005. Control patients consisted of 20 consecutive patients without TTP who presented to the emergency room (ER) with anemia and thrombocytopenia.Results: Patients with TTP had significantly elevated RDW compared with the controls (23.1% versus 17.2% respectively, P = 0.000 1). An RDW > 18% had a 95% sensitivity and 70% specificity in the diagnosis of TTP, whereas RDW > 19% had 80% sensitivity and 85% specificity.Conclusions: TTP should be suspected in patients presenting with unexplained anemia and thrombocytopenia with an RDW >= 18%.