Plasma levels of total plasminogen activator inhibitor-I (PAI-I) and tPA/PAI-1 complex in patients with disseminated intravascular coagulation and thrombotic thrombocytopenic purpura
Plasma levels of total plasminogen activator inhibitor-I (PAI-I) and tPA/PAI-1 complex in patients with disseminated intravascular coagulation and thrombotic thrombocytopenic purpura
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DOI：
10.1177/107602960100700309
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发表时间：
2001-07-01
影响因子：
2.9
通讯作者：
Nobori, T
中科院分区：
文献类型：
--
作者：
Watanabe, R;Wada, H;Nobori, T
在这项研究中，我们检测了弥散性血管内凝血（DIC）和血栓性血小板减少性紫癜（TTP）患者血浆中总纤溶酶原激活物抑制剂-I（PAI-I）和组织型纤溶酶原激活物（tPA）/PAI-I复合物的血浆水平变化，以研究纤溶功能及其与器官衰竭的关系。 DIG、DIG 前和 TTP 患者的血浆总 PAI-I 和 tPA/PAI-I 复合物水平显着高于非 DIG 患者。器官衰竭患者血浆中凝血酶-抗凝血酶复合物（TAT）、纤溶酶-纤溶酶抑制剂复合物（PPIC）、D-二聚体、血栓调节蛋白（TM）、总PAI-I和tPA/PAI-I复合物的水平显着高于无器官衰竭患者。急性白血病患者血浆总PAI-I和tPA/PAI-I复合物水平显着升高。在脓毒症或实体癌患者中，总 PAI-I 的血浆水平显着升高，但 tPA/PAI-I 复合物的血浆水平没有显着升高。在所有情况下，总 PAI-I 或 tPA/PAI-I 复合物与任何止血标志物均不显着相关。总 PAI-I 和 tPA/PAI-I 复合物的测量可能有助于 DIG 的诊断。
In this study, we examined changes in the plasma levels of total plasminogen activator inhibitor-I (PAI-I) and tissue-type plasminogen activator (tPA)/PAI-I complex in patients with disseminated intravascular coagulation (DIC) and in those with thrombotic thrombocytopenic purpura (TTP) to investigate the fibrinolytic function and its relation to organ failure. The plasma levels of total PAI-I and tPA/PAI-I complex were significantly higher in patients with DIG, pre-DIG, and TTP than in those with non-DIG. The plasma levels of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC), D-dimer, thrombomodulin (TM), total PAI-I, and tPA/PAI-I complex were significantly higher in patients with organ failure than in those without organ failure. The plasma levels of total PAI-I and tPA/PAI-I complex were markedly increased in patients with acute leukemia. The plasma levels of total PAI-I, but not those of tPA/PAI-I complex, were significantly increased in patients with sepsis or with solid cancer. In all cases, total PAI-I or tPA/PAI-I complex was not significantly correlated with any hemostatic marker. Measurement of total PAI-I and tPA/PAI-I complex may be useful in the diagnosis of DIG.