The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis
The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis
复制标题
DOI：
10.1016/j.neuroimage.2008.05.059
复制
发表时间：
2008-09-01
期刊：
影响因子：
5.7
通讯作者：
Marrelec, Guillaume
中科院分区：
文献类型：
--
作者：
Fransson, Peter;Marrelec, Guillaume
最近的研究表明，通过功能性磁共振成像（fMRI）观察到的内在脑活动表现为跨越长距离神经元通路的脑区域网络中的相干信号变化。这些网络之一，所谓的默认模式网络已成为最近研究的主要目标，将内在活动与认知联系起来，以及内在信号变化如何在疾病中改变。在这项研究中，我们评估了默认模式网络在休息和连续工作记忆任务中的功能连接，在一个区域一个区域的基础上使用偏相关分析，数据驱动的方法，提供洞察神经元网络内的有效连接。默认模式网络内功能连接的突出特征包括楔前叶/后扣带区域与默认模式网络其余部分之间的整体强水平的相互作用，以及左内侧颞叶和右内侧颞叶之间的高度相互作用，以及内侧颞叶与默认模式网络其余部分之间的弱相互作用。此外，我们发现支持楔前叶/后扣带皮层和左下顶叶之间以及内侧前额叶皮层的背侧和腹侧部分之间的强烈相互作用。建议楔前叶/后扣带皮层在默认模式网络中的重要作用进行了讨论。(c)2008年爱思唯尔公司All rights reserved.
Recent research has shown that intrinsic brain activity as observed by functional magnetic resonance imaging (fMRI) manifest itself as coherent signal changes in networks encompassing brain regions that span long-range neuronal pathways. One of these networks, the so called default mode network has become the, primary target in recent investigations to link intrinsic activity to cognition and how intrinsic signal changes may be altered in disease. In this study we assessed functional connectivity within the default mode network during both rest and a continuous working memory task on a region-by-region basis using partial correlation analysis, a data-driven method that provides insight into effective connectivity within neuronal networks. Prominent features of functional connectivity within the default mode network included an overall strong level of interaction between the precuneus/posterior cingulate region and the rest of the default mode network, as well as a high degree of interaction between the left and right medial temporal lobes combined with weak interactions between the medial temporal lobes and the rest of the default mode network. Additionally, we found support for strong interactions between the precuneus/posterior cingulate cortex and the left inferior parietal lobe as well as between the dorsal and ventral sections of the medial prefrontal Cortex. The suggested Pivotal role of the precuneus/posterior cingulate cortex in the default mode network is discussed. (c) 2008 Elsevier Inc. All rights reserved.