Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia
Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia
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DOI：
10.1007/s13539-012-0078-2
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发表时间：
2012-09-01
影响因子：
8.9
通讯作者：
Vellas, Bruno
中科院分区：
文献类型：
--
作者：
Cesari, Matteo;Fielding, Roger A.;Vellas, Bruno
肌肉减少症是与年龄相关的骨骼肌衰退，与老年人的相关临床和社会经济负面结果相关。对这一现象的研究和制定预防/治疗战略是公共卫生的优先事项。本文件报告了2011年6月7日至8日在图卢兹（法国）举行的肌肉减少症国际工作组（由来自学术界和工业界的老年病学家和科学家组成的工作组）最近一次会议的结果。该会议特别关注了解目前可用的生物标志物（功能性，生物学或成像相关），这些生物标志物可用于肌肉减少症的临床试验，并被认为是最可靠和最有前途的评估骨骼肌年龄相关变化的方法。还讨论并最终确定了关于老年人骨骼肌老化评估的具体建议和关于肌肉减少症研究的最佳方法设计。虽然骨骼肌衰退的研究仍处于非常初步的阶段，但更好地理解和治疗这种疾病所带来的潜在巨大益处应鼓励对肌肉减少症的研究。然而，合理的不确定性（来自探索一个新的领域和科学进步的指数加速）要求对这个问题采取谨慎和全面的方法。
Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic strategies represent public health priorities. The present document reports the results of a recent meeting of the International Working Group on Sarcopenia (a task force consisting of geriatricians and scientists from academia and industry) held on June 7-8, 2011 in Toulouse (France). The meeting was specifically focused at gaining knowledge on the currently available biomarkers (functional, biological, or imaging-related) that could be utilized in clinical trials of sarcopenia and considered the most reliable and promising to evaluate age-related modifications of skeletal muscle. Specific recommendations about the assessment of aging skeletal muscle in older people and the optimal methodological design of studies on sarcopenia were also discussed and finalized. Although the study of skeletal muscle decline is still in a very preliminary phase, the potential great benefits derived from a better understanding and treatment of this condition should encourage research on sarcopenia. However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject.