Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance.
Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance.
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DOI：
10.1158/0008-5472.can-14-3225
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发表时间：
2015-03-15
期刊：
影响因子：
11.2
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Adorno-Cruz V;Kibria G;Liu X;Doherty M;Junk DJ;Guan D;Hubert C;Venere M;Mulkearns-Hubert E;Sinyuk M;Alvarado A;Caplan AI;Rich J;Gerson SL;Lathia J;Liu H
为了消除癌症的根源，消除转移的种子，克服治疗抵抗，2014年在俄亥俄州克利夫兰举行的首届国际癌症干细胞（CSC）会议召集了320多名研究人员，其中包括55名受邀的世界级演讲者，25名简短的口头演讲者和100名海报演讲者。深入了解CSC，探索针对CSC的治疗机会。这次会议就几个主题进行了有趣的讨论，包括：遗传学和表观遗传学;癌症起源和演变;微环境和外泌体;代谢和炎症;转移和治疗耐药性;单细胞和异质性;可塑性和重编程;以及其他新概念。靶向CSC的临床试验报告强调迫切需要战略性地设计针对癌症的CSC靶向组合疗法。
With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at Cleveland, OH, convened together over 320 investigators, including 55 invited world-class speakers, 25 short oral presenters, and 100 poster presenters, to gain an in-depth understanding of CSCs and explore therapeutic opportunities targeting CSCs. The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts. Reports of clinical trials targeting CSCs emphasized the urgent need for strategically designing combinational CSC-targeting therapies against cancer.