STEROID-HORMONE RECEPTOR CONTENT AND LYMPH-NODE STATUS IN ENDOMETRIAL CANCER
STEROID-HORMONE RECEPTOR CONTENT AND LYMPH-NODE STATUS IN ENDOMETRIAL CANCER
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DOI：
10.1006/gyno.1995.1072
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发表时间：
1995-03-01
影响因子：
4.7
通讯作者：
BULLER, RE
中科院分区：
文献类型：
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作者：
MORRIS, PC;ANDERSON, JR;BULLER, RE
本研究的目的是将子宫内膜腺癌的类固醇激素受体状态与肿瘤转移到盆腔和主动脉旁淋巴结以及其他已知的影响生存的预后变量相关联。采用葡聚糖包被活性炭技术，对85例子宫内膜鳞状细胞样腺癌或鳞状细胞分化腺癌患者的肿瘤样本进行细胞质类固醇激素受体检测。类固醇激素受体含量与淋巴结状态相关，沿着其他预后变量，如患者的年龄、子宫肌层浸润深度、肿瘤分级和盆腔细胞学检查。通过单因素分析，淋巴结受累的可能性与年轻和低分化肿瘤相关。多因素分析显示，年龄、肿瘤分级和子宫肌层受累增加了重要的独立预后信息。雌激素或孕激素受体的含量并没有增加独立的预后信息淋巴结状态，一旦其他因素得到控制。子宫腺癌雌激素和孕激素受体结合状态的知识并不能取代仔细的淋巴结取样所提供的预后信息。(C)出版社：Academic Press
The purpose of this study was to correlate the steroid hormone receptor status in endometrial adenocarcinoma with tumor metastasis to the pelvic and para-aortic lymph nodes, and with other known prognostic variables which influence survival. Tumor samples from 85 patients with endometrioid adenocarcinoma, or adenocarcinoma with squamous differentiation of the endometrium who underwent complete surgical staging, were assayed for cytoplasmic steroid hormone receptors using a dextran-coated charcoal technique. Steroid hormone receptor content was correlated to lymph node status, along with other prognostic variables, such as patient's age, depth of myometrial invasion, tumor grade, and pelvic cytology. By univariate analysis, the likelihood of nodal involvement was associated with younger age and poorly differentiated tumors. Multivariate analysis revealed that age, tumor grade, and myometrial involvement added significant independent prognostic information. Estrogen or progesterone receptor content did not add independent prognostic information concerning lymph node status once other factors were controlled. Knowledge of estrogen and progesterone receptor binding status in adenocarcinoma of the uterus does not replace the prognostic information imparted by careful sampling of lymph nodes. (C) 1995 Academic Press, Inc.