Enterococcus faecium strain R30 increases red blood cell velocity and prevents capillary regression in the soleus of hindlimb unloaded rats via the eNOS/VEGF pathway.
Enterococcus faecium strain R30 increases red blood cell velocity and prevents capillary regression in the soleus of hindlimb unloaded rats via the eNOS/VEGF pathway.
复制标题
屎肠球菌 R30 菌株通过 eNOS/VEGF 途径增加红细胞速度，并防止后肢无负载大鼠的比目鱼肌毛细血管退化。
DOI：
10.1111/micc.12356
复制
发表时间：
2017
期刊：
影响因子：
2.4
通讯作者：
Fujino H.
中科院分区：
文献类型：
--
作者：
Hirayama Y;Nakanishi R;Tategaki A;Maeshige N;Kondo H;Ishihara A;Roy RR;Fujino H.
神经肌肉活动的慢性减少导致骨骼肌萎缩和毛细血管退化。本研究的目的是确定的影响ofEnterococcus faecium菌株R30（R30）管理上（i）大鼠比目鱼肌的血液动力学，和（ii）毛细血管退化通常与HU.MethodsExperiment 1：TheVRBC测量长达1小时后，R30与或不与β受体阻滞剂普萘洛尔。实验2：对照组和HU组大鼠每天给予R30，持续2周。平均毛细血管管腔直径，体积，和eNOS和VEGF蛋白的水平进行了measured.ResultsExperiment1：VRBC是快20，40，60分钟后，比之前的管理R30：这种效果被抑制普萘洛尔管理。实验二：在HU期间R30管理增加毛细血管管腔直径和体积和eNOS和VEGF蛋白水平在HU rates.ConclusionsThe结果表明，R30增加VRBC在比目鱼肌通过肌肉交感神经活动（实验1）和R30补充减少毛细血管退化通常与HU通过eNOS/VEGF通路（实验2）。
ObjectiveA chronic decrease in neuromuscular activity results in atrophy and capillary regression in skeletal muscles. The purposes of this study were to determine the effects ofEnterococcus faeciumstrain R30 (R30) administration on (i) the hemodynamics of the rat soleus muscle, and (ii) the capillary regression normally associated with HU.MethodsExperiment 1: TheVRBCwas measured for up to 1 hour after administration of R30 with or without the β‐blocker propranolol. Experiment 2: R30 was administered daily to control and HU rats for 2 weeks. Mean capillary luminal diameter, volume, and the levels of eNOS and VEGF protein were measured.ResultsExperiment 1:VRBCwas faster 20, 40, and 60 minutes after than before the administration of R30: This effect was suppressed by propranolol administration. Experiment 2: R30 administration during HU increased capillary luminal diameter and volume and eNOS and VEGF protein levels in the soleus of HU rats.ConclusionsThe results suggest that R30 increasesVRBCin the soleus muscle via muscle sympathetic nerve activity (Experiment 1) and that R30 supplementation lessens the capillary regression normally associated with HU via the eNOS/VEGF pathway (Experiment 2).