GLUCOCORTICOIDS AND MINERALOCORTICOIDS MAY REGULATE THE NATRIURETIC EFFECT AND THE SYNTHESIS AND RELEASE OF ATRIAL NATRIURETIC FACTOR BY THE RAT ATRIA INVIVO
GLUCOCORTICOIDS AND MINERALOCORTICOIDS MAY REGULATE THE NATRIURETIC EFFECT AND THE SYNTHESIS AND RELEASE OF ATRIAL NATRIURETIC FACTOR BY THE RAT ATRIA INVIVO
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DOI：
10.1016/0006-291x(85)91311-7
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发表时间：
1985-01-01
影响因子：
3.1
通讯作者：
CANTIN, M
中科院分区：
文献类型：
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作者：
GARCIA, R;DEBINSKI, W;CANTIN, M
肾上腺切除术取消了ANF的急性利钠作用，通过糖皮质激素和盐皮质激素的联合治疗，ANF可能恢复到约50%。这表明，缺乏ANF的效果可能是由于减少肾血管反应性的肽肾上腺切除动物。同时给予地塞米松和醋酸脱氧皮质酮肾上腺切除大鼠心房组织和血浆中的免疫反应性心钠素显着增加。这些动物的NaCl管理产生了相对较低的心房ANF浓度和血浆ANF的进一步增加。我们的研究结果表明，糖皮质激素可能调节合成和释放的心钠素的动脉和盐皮质激素可能有一个许可的作用。此外，类固醇的存在对于NaCl刺激的ANF释放是必要的。
Adrenalectomy abolished the acute natriuretic effect of ANF which was potentially restored to about 50% by combined therapy with gluco- and mineralocorticoids. It is suggested that the lack of effect of ANF may be due to a decrease renal vascular reactivity to the peptide in adrenalectomized animals. Simultaneous administration of Dexamethasone and Deoxycorticosterone acetate to adrenalectomized rats produced a marked increase in immunoreactive ANF in atrial tissue and plasma. The administration of NaCl to these animals produced a relatively lower concentration of atrial ANF and a further increase in plasma ANF. Our results suggest that glucocorticoids may regulate synthesis and release of ANF by the artria and mineralocorticoids may have a permissive role. Furthermore, the presence of steroids is necessary for the NaCl-stimulated ANF release.