Extensive genetic diversity in Blastocystis hominis
Extensive genetic diversity in Blastocystis hominis
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DOI：
10.1016/s0166-6851(97)00046-7
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发表时间：
1997-07-01
影响因子：
1.5
通讯作者：
Clark, CG
中科院分区：
文献类型：
--
作者：
Clark, CG
人芽囊原虫是一种常见的人体寄生虫，在人类疾病中的作用尚不明确。大约有相同数量的报告将其作为一种病原体牵连并免除其责任。B的遗传多样性。使用Riboprinting研究了30个随机选择的分离株的小亚基核糖体RNA基因的序列变异。在B中发现了广泛的序列变异。hominis核糖体RNA基因，该物种由至少7种形态上相同但遗传上完全不同的生物体组成。如果仅是B的子集。人的变异有可能导致人类疾病，这可能解释了报告的不同发现。未来的临床研究必须考虑B的异质性。人的考虑。(C)1997年Elsevier Science B.V.
Blastocystis hominis is a common human parasite of uncertain role in human disease. Approximately equal numbers of reports implicate it and exonerate it as a pathogen. Genetic diversity in B. hominis was investigated using riboprinting to study sequence variation in the small subunit ribosomal RNA genes of 30 randomly selected isolates. Extensive sequence variation was discovered in B. hominis ribosomal RNA genes and this species consists of at least seven morphologically identical but genetically quite distinct organisms. If only a subset of the B. hominis variants have the potential to cause disease in humans this might explain the disparate findings reported. Future clinical studies must take the heterogeneity of B. hominis into account. (C) 1997 Elsevier Science B.V.