Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey
Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey
复制标题
白三烯 C4 影响猴子的肺和心血管动力学
作者：
G. Smedegård;P. Hedqvist;S. Dahlén;B. Revenäs;S. Hammarström;B. Samuelsson
白三烯C4（LTC4）及其代谢物LTD4和LTE4（图1）已被确定为过敏反应慢反应物质（SRS-A）1-3的主要活性成分。白三烯 C4、D4 和 E4 已迅速获得认可，被认为是在豚鼠体内和体外 4-7 中具有迄今为止无与伦比的效力的支气管收缩剂，并且在豚鼠 3,5,7 和仓鼠 8 中充当水肿形成物质。在这里，我们报告 LTC4 也是猴子中重要的支气管收缩剂；它主要通过降低肺动态顺应性来增加麻醉动物的跨肺压，并收缩孤立的气管螺旋组织。此外，LTC4 会引起短暂性肺动脉高压和全身性高血压，随后导致长时间的低血压，并伴有心输出量减少、血液浓缩和循环白细胞数量减少。这些在灵长类动物体内的发现表明，白三烯也可能导致人类心血管和肺功能的重要改变。
Leukotriene C4 (LTC4) and its metabolites LTD4 and LTE4 (Fig. 1) have been identified as the major active constituents of slow-reacting substance of anaphylaxis (SRS-A)1–3. Leukotrienes C4, D4 and E4 have rapidly gained recognition as bronchoconstrictors of hitherto unsurpassed potency in the guinea pig in vivo and in vitro4–7 as well as acting as oedema-forming substances in guinea pig3,5,7 and hamster8. Here we report that LTC4 is also a prominent bronchoconstrictor in the monkey; it increases transpulmonary pressure in the anaesthetized animal, mainly by decreasing pulmonary dynamic compliance, and it contracts isolated tracheal spiral tissue. Furthermore, LTC4 causes transient pulmonary and systemic hypertension, followed by a prolonged hypotensive period associated with decreased cardiac output, haemoconcentration and reduction in the number of circulating leukocytes. These in vivo findings in a primate imply that leukotrienes may also cause important alterations of cardiovascular and pulmonary function in man.
DOI：
10.1073/pnas.77.7.4354
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
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作者：
DRAZEN, JM;AUSTEN, KF;COREY, EJ
通讯作者：
COREY, EJ