T cell competence to heterologous and homologous thyroglobulins during the induction of experimental autoimmune thyroiditis
T cell competence to heterologous and homologous thyroglobulins during the induction of experimental autoimmune thyroiditis
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实验性自身免疫性甲状腺炎诱导过程中 T 细胞对异源和同源甲状腺球蛋白的能力
DOI：
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发表时间：
1984
影响因子：
5.4
通讯作者：
W. Weigle
中科院分区：
文献类型：
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作者：
C. G. Romball;W. Weigle
T细胞对同种和异种甲状腺球蛋白(TG)的反应能力已经用不同的模型进行了评估，以诱导实验性自身免疫性甲状腺炎。在完全弗氏佐剂中免疫异种甘油三酯后，异种甘油三酯的T细胞活化水平较高，而在完全弗氏佐剂中免疫同种异体甘油三酯后，T细胞对同种甘油三酯的活化程度很低。使用该免疫方案，异种和同源TG诱导的血清抗体水平与免疫TG相当。然而，当注射不完全弗氏佐剂时，同种甘油三酯产生的抗体比异种甘油三酯少。可溶性甘油三酯免疫后，血清中对异种和同种甘油三酯的抗体水平有更大的差异。这些差异归因于同种TG只存在最低水平的T细胞活性，这种T细胞能够在严格的免疫方案下诱导实验性自身免疫性甲状腺炎，而不是在较弱的免疫方案下。
The ability of T cells to respond to homologous vs. heterologous thyroglobulins (Tg) has been evaluated using different models for the induction of experimental autoimmune thyroiditis. Substantial levels of T cell activation could be demonstrated to heterologous Tg following immunization with heterologous Tg in complete Freund's adjuvant, whereas only minimal levels of T cell activation to homologous Tg could be obtained following immunization with homologous Tg in complete Freund's adjuvant. Using this immunization protocol, heterologous and homologous Tg induced equivalent levels of serum antibody to the immunizing Tg. However, when injected in incomplete Freund's adjuvant, homologous Tg induced less antibody than heterologous Tg. Even greater differences in serum antibody levels to heterologous and homologous Tg were apparent following immunization with soluble Tg. These differences are attributed to the presence of only a minimal level of T cell competence for homologous Tg, which is capable of inducing experimental autoimmune thyroiditis with stringent immunization protocols, but not with weaker immunization regimens.