Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell
Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell
复制标题
DOI：
10.1007/s11418-021-01528-8
复制
发表时间：
2021-05-15
影响因子：
3.3
通讯作者：
Watanabe, Tetsushi
中科院分区：
文献类型：
--
作者：
Kitagawa, Takahiro;Matsumoto, Takahiro;Watanabe, Tetsushi
从厚叶山柑果实和香橙果皮中分离得到两个新的柠檬苦素类化合物，即金柑酮（fortunellone）和朱诺素（junosol），以及诺米林（nomilin）等三个已知化合物。新化合物的化学结构根据化学/物理化学证据进行了鉴定。对于fortunellone，通过比较实验和预测的电子圆二色性（ECD）数据，建立了绝对构型。阿霉素（ADR）处理的人宫颈癌细胞（HeLa）上的死亡细胞数显著增加。另一方面，fortunellon和nomilin并不能单独影响死亡细胞的数量。结果提示，扶芳藤酮和诺米林可能具有作为化疗增效剂的潜力。[图形]。
From the fruits of Fortunella crassifolia and the peels of Citrus junos, two new limonoids, fortunellone and junosol were isolated together with three known compounds including nomilin. The chemical structures of the new compounds were elucidated based on chemical/physicochemical evidence. For fortunellone, the absolute configuration was established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Fortunellon and nomilin significantly increased the number of dead cells on adriamycin (ADR)-treated human cervical cancer cells (HeLa). On the other hand, fortunellon and nomilin did not affects the number of dead cells alone. These results suggested that fortunellone and nomilin may have the potency as the chemotherapy enhancement agents.[GRAPHICS].