CATECHOLAMINE INNERVATION OF BASAL FOREBRAIN .4. TOPOGRAPHY OF DOPAMINE PROJECTION TO BASAL FOREBRAIN AND NEOSTRIATUM
CATECHOLAMINE INNERVATION OF BASAL FOREBRAIN .4. TOPOGRAPHY OF DOPAMINE PROJECTION TO BASAL FOREBRAIN AND NEOSTRIATUM
复制标题
DOI：
10.1002/cne.901800310
复制
发表时间：
1978-01-01
影响因子：
2.5
通讯作者：
MOORE, RY
中科院分区：
文献类型：
--
作者：
FALLON, JH;MOORE, RY
应用乙醛酸荧光组织化学技术，对大鼠中脑喙部多巴胺（DA）神经元胞体进行了定位。随后，这些中脑神经元的基底前脑和纹状体的投射的地形图进行了分析，使用顺行运输放射自显影追踪方法和逆行运输辣根过氧化物酶（HRP）技术。这些解剖学研究的结果与以前报告中提出的生物化学和组织化学研究相关联，以提供以下结论。基底前脑和新纹状体的DA神经元投射的地形学组织在3个平面，背腹侧，内侧和前后。DA细胞几乎只存在于黑质（SN）和腹侧被盖区（VTA）。SN和VTA的神经细胞投射到基底前脑的背侧结构，如隔、中脑核和新纹状体。后者包括位于SN网状部腹侧的一些DA细胞。背侧细胞向腹侧结构突出。内侧-外侧地形的组织，使内侧部门的SN-VTA区项目的内侧部分的核在基底前脑和新纹状体，而外侧部门的SN-VTA区项目的外侧部分的核在基底前脑和新纹状体。前-后地形也很明显，因此SN-VTA的前部向前突出，而在这些区域中，后部SN-VTA更向后突出。这些观察结果是一致的，认为DA神经元的SN-VTA复合体形成一个单一的核组具有高度地形组织的投影支配的端脑和allocortical结构的深核。
The location of dopamine (DA) neuron perikarya in the rostal mesencephalon of the rat was determined using the glyoxylic acid fluorescence histochemical technique. Subsequently the topography of the projection of these mesencephalic neurons on the basal forebrain and striatum was analyzed using the anterograde transport-autoradiographic tracing method and the retrograde transport-horseradish peroxidase (HRP) technique. The results of these anatomical studies were correlated with the biochemical and histochemical studies presented in previous reports, to provide the following conclusions. The topography of the DA neuron projection on the basal forebrain and neostriatum is organized in 3 planes, dorsal-ventral, medial-lateral and anterior-posterior. DA cells are found almost exclusively in the substantia nigra (SN) and ventral tegmental area (VTA). Ventral cells of the SN and VTA project to the dorsal structures of the basal forebrain such as the septum, nucleus accumbens and neostriatum. The latter includes some DA cells located ventrally in the pars reticulata of the SN. Dorsal cells project to ventral structures. The medial-lateral topography is organized so that the medial sectors of the SN-VTA area project to the medial parts of nuclei in the basal forebrain and neostriatum whereas lateral sectors of the SN-VTA area project to the lateral parts of nuclei in the basal forebrain and neostriatum. An anterior-posterior topography also is evident so that anterior parts of the SN-VTA project anteriorly whereas the posterior SN-VTA projects more posteriorly in these areas. These observations are consistent with the view that the DA neurons of the SN-VTA complex form a single nuclear group with a highly topographically organized projection innervating both deep nuclei of the telencephalon and allocortical structures.