Association of serum cytokines with colorectal polyp number and type in adult males.
Association of serum cytokines with colorectal polyp number and type in adult males.
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DOI：
10.1097/cej.0000000000000160
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发表时间：
2016-05
期刊：
影响因子：
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通讯作者：
Fenton JI
中科院分区：
文献类型：
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作者：
Comstock SS;Xu D;Hortos K;Kovan B;McCaskey S;Pathak DR;Fenton JI
慢性炎症有助于结直肠癌的发生。为了确定血清细胞因子是否与结肠息肉有关，126名无症状男性(48-65岁)接受了结肠镜检查。测定血清细胞因子浓度。采用多分类Logistic回归分析息肉数量和类型的优势比。血清单核细胞趋化蛋白-3(MCP-3)或可溶性白介素4受体(sIL-4R)水平最高的男性发生≥-3息肉的可能性是无息肉的0.2倍。血清MCP-3或sIL-4R每升高一次，男性患≥-3息肉的可能性就比没有息肉低0.4倍。血清干扰素-α-2(干扰素-α-2)或白介素7(IL-7)浓度最高的男性患腺瘤的可能性是无息肉的3倍。那些血清IL-8浓度最高的人患腺瘤的可能性是无息肉的4倍。血清干扰素-α-2、IL-7或IL-8每升高一次，患腺瘤的可能性是无息肉的1.8倍。血清单核细胞趋化蛋白-3、sIL-4R、干扰素-α-2、IL-7和IL-8水平可提示哪些男性更容易发生大肠息肉。
Chronic inflammation contributes to colorectal carcinogenesis. To determine if serum cytokines are associated with colon polyps, 126 asymptomatic men (48–65yr) were recruited at colonoscopy. Serum cytokine concentrations were measured. Odds ratios were determined using polytomous logistic regression for polyp number and type. Males with serum monocyte chemotactic protein-3 (MCP-3) or soluble interleukin-4 receptor (sIL-4R) concentrations in the highest tertile were 0.2 times less likely to have ≥3 polyps relative to no polyps. For each increase in serum MCP-3 or sIL-4R tertile a man was about 0.4 times less likely to have ≥3 polyps than no polyps. Males with serum concentrations of interferon-α2 (IFN-α2) or interleukin (IL)-7 in the highest tertile were 3 times more likely to have an adenoma relative to no polyps. Those with serum IL-8 concentrations in the highest tertile were 4 times more likely to have an adenoma relative to no polyps. For each increase in serum IFN-α2, IL-7 or IL-8 tertile an individual was 1.8 times more likely to have an adenoma than no polyp. Serum concentrations of MCP-3, sIL-4R, IFN-α2, IL-7 and IL-8 may indicate which men are more likely to have colorectal polyps.