Sex differences in obstructive sleep apnoea
Sex differences in obstructive sleep apnoea
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DOI：
10.1183/16000617.0030-2019
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发表时间：
2019-12-31
影响因子：
7.5
通讯作者：
Riha, Renata L.
中科院分区：
文献类型：
--
作者：
Bonsignore, Maria R.;Saaresranta, Tarja;Riha, Renata L.
阻塞性睡眠呼吸暂停（OSA）和阻塞性睡眠呼吸暂停/呼吸不足综合征（OSAHS）一直被认为是主要与男性有关的条件。女性睡眠呼吸障碍的临床表现与男性不同，并且可以随年龄和生理状态而变化，例如绝经和怀孕。总体而言，与男性相比，女性似乎更有症状，呼吸暂停-呼吸不足指数评分较低。此外，他们似乎有更长时间的部分上呼吸道阻塞，并可能报告失眠作为OSAHS的症状更频繁。由于临床表现的这些差异，与男性相比，患有睡眠呼吸障碍的女性往往诊断不足和治疗不足。本文旨在讨论流行病学，临床表现，病理生理和激素和代谢的差异，女性谁目前与OSA/OSAHS相比，男性。
Obstructive sleep apnoea (OSA) and obstructive sleep apnoea/hypopnoea syndrome (OSAHS) have long been considered predominantly male-related conditions. The clinical presentation of sleep disordered breathing in females differs from males and can vary with age and physiological status, e.g. menopause and pregnancy. Overall, females appear to be more symptomatic, with lower apnoea-hypopnoea index scores compared to males. Furthermore, they appear to have more prolonged partial upper airway obstruction, and may report insomnia as a symptom of OSAHS more frequently. As a consequence of these differences in clinical presentation, females with sleep disordered breathing are often underdiagnosed and undertreated compared to males. This review is aimed at discussing the epidemiology, clinical presentation, pathophysiology and hormonal and metabolic differences in females who present with OSA/OSAHS in comparison to males.