PULMONARY-FUNCTION AND SYMPTOM RESPONSES AFTER 6.6-HOUR EXPOSURE TO 0.12 PPM OZONE WITH MODERATE EXERCISE
PULMONARY-FUNCTION AND SYMPTOM RESPONSES AFTER 6.6-HOUR EXPOSURE TO 0.12 PPM OZONE WITH MODERATE EXERCISE
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DOI：
10.1080/08940630.1988.10466349
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发表时间：
1988-01-01
期刊：
影响因子：
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通讯作者：
HORSTMAN, DH
中科院分区：
文献类型：
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作者：
FOLINSBEE, LJ;MCDONNELL, WF;HORSTMAN, DH
当环境臭氧（O3）水平保持在0.12 ppm或接近0.12 ppm超过6小时时，偶尔会发生Epilepsy。据报道，暴露于0.12 ppm O3 2小时后，肺功能会出现小幅下降。对于短时间暴露于较高的O3浓度，肺功能递减是暴露持续时间的函数。因此，我们研究了这一假设，即长期暴露于0.12 ppm的O3会导致呼吸功能和症状随着时间的推移逐渐发生更大的变化。10名不吸烟的男性（18-33岁）暴露于清洁空气和0.12 ppm O3一次6.6小时。暴露包括6个50分钟的运动期，每个运动期后10分钟的休息和测量; 35分钟的午餐期后的第三个运动期。运动通气量平均约为40 L/min。在暴露前和每次运动后测量用力呼气和吸气肺活量测定法和呼吸症状。每次暴露后测定气道对乙酰甲胆碱的反应性。在空气暴露校正后，发现FEV1.0在O3暴露期间线性下降，并在暴露结束时平均下降13.0%（591 mL）。在暴露结束时，FVC和FEF 25 -75%的下降也是线性的，平均分别为8.3%和17.4%。在用力吸气试验中，FIVC和FIVO 5分别下降了12.6%和20.7%。在O3暴露下观察到深吸气时咳嗽和疼痛的症状评分增加，但在清洁空气下没有观察到。O3暴露后，气道对乙酰甲胆碱的反应性大约增加了一倍。我们的结论是，长期暴露于0.12 ppm的O3导致呼吸功能的渐进性变化，非特异性气道反应性显着增加，症状的渐进性变化。
Episodes occasionally occur when ambient ozone (O3) levels remain at or near 0.12 ppm for more than 6 h. Small decrements in lung function have been reported following 2-h exposures to 0.12 ppm O3. For short exposures to higher O3 concentrations, lung function decrements are a function of exposure duration. Thus, we investigated the hypothesis that prolonged exposure to 0.12 ppm O3 would result in progressively larger changes in respiratory function and symptoms over time. Ten nonsmoking males (18-33 yr) were exposed once to clean air and once to 0.12 ppm O3 for 6.6 h. Exposures consisted of six 50-min exercise periods, each followed by 10-min rest and measurement; a 35-min lunch period followed the third exercise period. Exercise ventilation averaged approximately 40 L/min. Forced expiratory and inspiratory spirometry and respiratory symptoms were measured prior to exposure and after each exercise. Airway reactivity to methacholine was determined after each exposure. After correcting for the air exposures, FEV 1.0 was found to decrease linearly during the O3 exposure and was decreased by an average of 13.0 percent (591 mL) at the end of exposure. Decreases in FVC and FEF25-75% were also linear and averaged 8.3 and 17.4 percent, respectively, at the end of exposure. On forced inspiratory tests, the FIVC and FIVO5 were decreased 12.6 and 20.7 percent, respectively. Increases in the symptom ratings of cough and pain on deep inspiration were observed with O3 exposure but not with clean air. Airway reactivity to methacholine was approximately doubled following O3 exposure. We conclude that prolonged exposure to 0.12 ppm O3 results in progressive changes in respiratory function, a marked increase in nonspecific airway reactivity, and progressive changes in symptoms.