Management of Life-Threatening AcidBase Disorders

Management of Life-Threatening AcidBase Disorders
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危及生命的酸碱紊乱的治疗

DOI:
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发表时间:
1998
期刊:
影响因子:
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通讯作者:
N. Madias
N. Madias
中科院分区:
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文献类型:
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作者:
H. Adrogue;N. Madias

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Adverse Consequences of Severe Alkalemia Severe alkalemia (blood pH greater than 7.60) can compromise cerebral and myocardial perfusion by causing arteriolar constriction, an effect that is more pronounced in respiratory than in metabolic alkalosis (Table 2).69–71 Neurologic abnormalities may ensue, including headache, tetany, seizures, lethargy, delirium, and stupor. The associated reduction in the plasma concentration of ionized calcium probably contributes to these manifestations. Although it exerts a moderate positive inotropic effect on the isolated heart, alkalemia reduces the anginal threshold and predisposes the patient to refractory supraventricular and ventricular arrhythmias. This arrhythmogenic action is more pronounced in patients with . . .
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发表时间: 1985
期刊: The Journal of clinical investigation
影响因子: --
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