Influence of age on whole-body retention and distribution of 115m Cd in the rat.
Influence of age on whole-body retention and distribution of 115m Cd in the rat.
复制标题
年龄对大鼠全身 115m Cd 保留和分布的影响。
DOI：
10.1016/0013-9351(77)90071-8
复制
发表时间：
1977
影响因子：
8.3
通讯作者：
K. Kostial
中科院分区：
文献类型：
--
作者：
D. Kello;K. Kostial
The influence of age on whole-body retention and organ distribution of intraperitoneally applied115mCdCl2was studied in 1-, 3-, 6-, and 52-week-old rats. The mean percent values of115mCd retention in the whole body decreased with increasing age. The distribution of115mCd in the body on the 14th day after application shows that in all age groups most of the cadmium is accumulated in the liver (45–56%) and kidneys (4–6%). In younger rats the percentage of cadmium in the kidney and blood was always higher than in older animals in contrast to the liver where it was lower. The percentage of the dose in the liver, kidneys, and blood represents however, a considerably lower fraction of the total whole-body retention in younger animals than in older rats. It is therefore concluded that age bears a significant influence on cadmium metabolism. This might be important for estimating cadmium body burden and critical organ exposure in the youngest age group.
