Transcortical sensory aphasia: revisited and revised
Transcortical sensory aphasia: revisited and revised
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DOI：
10.1093/brain/123.8.1634
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发表时间：
2000-08-01
期刊：
影响因子：
14.5
通讯作者：
Lenz, F
中科院分区：
文献类型：
--
作者：
Boatman, D;Gordon, B;Lenz, F
经皮质感觉性失语（TSA）的特征是听力理解受损，但重复完整，语言流畅。我们诱导TSA短暂的常规皮层功能映射过程中的6名成年癫痫患者的电干扰。对于每个患者，TSA与多个后皮质部位相关，包括经典Wernicke区的后上级和颞中回。在同一患者中，许多TSA部位紧邻引起韦尼克失语症的部位。语音解码的语音进行了评估，听觉音节歧视，并发现在TSA诱导的所有网站是完整的。在语言缺陷模式类似TSA的电极部位子集，命名和单词阅读保持完整。通过颈动脉注射异戊巴比妥进行的语言偏侧化测试没有发现独立的右半球语言的证据。这些结果表明，TSA可能是由于左半球语音和词汇语义加工之间的单向中断。
Transcortical sensory aphasia (TSA) is characterized by impaired auditory comprehension with intact repetition and fluent speech. We induced TSA transiently by electrical interference during routine cortical function mapping in six adult seizure patients. For each patient, TSA was associated with multiple posterior cortical sites, including the posterior superior and middle temporal gyri, in classical Wernicke's area. A number of TSA sites were immediately adjacent to sites where Wernicke's aphasia was elicited in the same patients. Phonological decoding of speech sounds was assessed by auditory syllable discrimination and found to be intact at all sites where TSA was induced. At a subset of electrode sites where the pattern of language deficits otherwise resembled TSA, naming and word reading remained intact. Language lateralization testing by intracarotid amobarbital injection shelved no evidence of independent right hemisphere language. These results suggest that TSA may result from a one-way disruption between left hemisphere phonology and lexical-semantic processing.