RNA interference pathways in fungi: mechanisms and functions.
RNA interference pathways in fungi: mechanisms and functions.
复制标题
DOI：
10.1146/annurev-micro-092611-150138
复制
发表时间：
2012
影响因子：
10.5
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Chang SS;Zhang Z;Liu Y
RNA干扰（RNA interference，RNAi）是一种保守的真核生物基因调控机制，利用非编码小RNA介导转录后/转录后基因沉默。自RNAi研究开始以来，裂殖酵母裂殖酵母和丝状真菌粗糙脉孢菌一直是重要的模型系统。对这两种生物和其他真菌的研究为我们理解RNAi在真核生物中的机制和功能做出了重要贡献。此外，在真菌中发现了令人惊讶的多种RNAi介导的过程和小RNA生物合成途径。本文综述了真菌RNAi途径的研究进展，重点介绍了真菌RNAi途径的作用机制和功能。
RNA interference (RNAi) is a conserved eukaryotic gene regulatory mechanism that uses small non-coding RNAs to mediate post-transcriptional/transcriptional gene silencing. The fission yeast Schizosaccharomyces pombe and the filamentous fungus Neurospora crassa have served as important model systems since the beginning of RNAi studies. Studies in these two organisms and other fungi have contributed significantly to our understanding of the mechanisms and functions of RNAi in eukaryotes. In addition, surprisingly diverse RNAi-mediated processes and small RNA biogenesis pathways have been discovered in fungi. In this review, an overview is given of different fungal RNAi pathways with a focus on their mechanisms and functions.