Hyperinflammation and Immune Response Generation in COVID-19
Hyperinflammation and Immune Response Generation in COVID-19
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DOI：
10.1159/000513198
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发表时间：
2020-12-18
影响因子：
2.4
通讯作者：
Singh, Shashi Bala
中科院分区：
文献类型：
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作者：
Mishra, Kamla Prasad;Singh, Ajay Kumar;Singh, Shashi Bala
导致2019冠状病毒病（COVID-19）大流行的严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）影响了全球数百万人。这种病毒的病理生理学还不是很清楚，因此，科学界正在做出巨大努力来描述其逃避机制。本文就SARS-CoV-2病毒感染后机体产生的炎症反应、体液免疫和细胞免疫反应进行综述。感染后由增加的促炎细胞因子和趋化因子以及补体蛋白激活产生的炎症反应可能有助于疾病的严重程度。我们还讨论了可能影响免疫力的其他因素，这些因素可能是疾病严重程度和结局的重要合并症。
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. The pathophysiology of this virus is not very clearly known, thus, enormous efforts are being made by the scientific community to delineate its evading mechanism. In this review, we have summarized the hyperinflammation and humoral and cell-mediated immune response generated in human body after infection with the SARS-CoV-2 virus. The inflammatory response generated after infection by increased proinflammatory cytokines and chemokines, and complement proteins activation may likely contribute to disease severity. We also discussed the other factors that may affect immunity and could be important comorbidities in the disease severity and outcome.