Effect of maternal coffee, smoking and drinking behavior on adult son's semen quality: prospective evidence from the Child Health and Development Studies.
Effect of maternal coffee, smoking and drinking behavior on adult son's semen quality: prospective evidence from the Child Health and Development Studies.
复制标题
孕产妇咖啡，吸烟和饮酒行为对成年儿子精液质量的影响：儿童健康与发展研究的前瞻性证据。
DOI：
10.1017/s2040174411000584
复制
发表时间：
2011-12
影响因子：
1.7
通讯作者：
Factor-Litvak P
中科院分区：
文献类型：
--
作者：
Cirillo PM;Cohn BA;Krigbaum NY;Lee M;Brazil C;Factor-Litvak P
胎儿暴露于咖啡因与不良妊娠结局相关。动物和人类研究表明，咖啡因可能对发育中的生殖系统有影响。在这里，我们报告了母亲的吸烟，咖啡和酒精的使用，在怀孕期间记录，并在38-47岁的年龄组的儿子精液质量。受试者是儿童健康与发展研究的一个子集，这是一个在1959年至1967年期间在加州奥克兰附近的凯撒基金会健康计划中登记的妊娠队列。2005年，成年儿子参加了一项随访研究（n = 338），196名参与者捐赠了精液样本。根据国家生殖医学合作网络（男性生育力研究）方案分析样本的精子浓度、活力和形态。与未暴露的儿子相比，产前高暴露（母亲每天使用5杯咖啡）的儿子的平均精子浓度减少了约1600万个精子（下降趋势的P值= 0.09），这意味着按比例减少了25%。活动精子的平均百分比下降约7个点（P值= 0.04），比例下降13%，正常形态精子的平均百分比下降约2个点（P值= 0.01），比例下降25%。母亲吸烟和饮酒与儿子的精液质量无关。调整儿子的当代咖啡，酒精和香烟的使用并不能解释母亲的联系。儿子的咖啡摄入量和父亲的产前咖啡，香烟和酒精的使用是不显着的，不确定的。这些结果有助于证明母亲在怀孕期间使用咖啡可能会损害男性胎儿的生殖发育。
Fetal exposure to caffeine is associated with adverse pregnancy outcomes. Animal and human studies suggest that caffeine may have effects on the developing reproductive system. Here we report on mothers' smoking, coffee and alcohol use, recorded during pregnancy, and semen quality in sons in the age group of 38–47 years. Subjects were a subset of the Child Health and Development Studies, a pregnancy cohort enrolled between 1959 and 1967 in the Kaiser Foundation Health Plan near Oakland, California. In 2005, adult sons participated in a follow-up study (n = 338) and semen samples were donated by 196 participants. Samples were analyzed for sperm concentration, motility and morphology according to the National Cooperative Reproductive Medicine Network (Fertile Male Study) Protocol. Mean sperm concentration was reduced by approximately 16 million sperms for sons with high prenatal exposure (5 cups of maternal coffee use per day) compared with unexposed sons (P-value for decreasing trend = 0.09), which translates to a proportionate reduction of 25%. Mean percent motile sperm decreased by approximately 7 points (P-value = 0.04), a proportionate decline of 13%, and mean percent sperm with normal morphology decreased by approximately 2 points (P-value = 0.01), a proportionate decline of 25%. Maternal cigarette and alcohol use were not associated with son's semen quality. Adjusting for son's contemporary coffee, alcohol and cigarette use did not explain the maternal associations. Findings for son's coffee intake and father's prenatal coffee, cigarette and alcohol use were non-significant and inconclusive. These results contribute to the evidence that maternal coffee use during pregnancy may impair the reproductive development of the male fetus.