Effects of radiotherapy fractionation on breast stromal activity.
Effects of radiotherapy fractionation on breast stromal activity.
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放射治疗分割对乳腺基质活性的影响。
DOI：
10.1109/iembs.2011.6090074
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Insana,MichaelF
中科院分区：
文献类型：
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作者：
Qayyum,MuqeemA;Insana,MichaelF
我们研究了生长因子和电离辐射（IR）结合联合收割机改变细胞微环境时肿瘤细胞进展的动力学。乳腺肿瘤的生长取决于癌细胞在其微环境中的行为，并且这两种成分都受到IR分馏参数的影响。TGF-β1促进成纤维细胞向肌成纤维细胞的分化，其使细胞外基质（ECM）变硬并促进恶性细胞表型。IR产生活性氧物质（ROS），其损伤和灭活细胞，从而控制增殖。使用MRC-5成纤维细胞在3-D胶原培养物中研究了不同分数大小的TGF-β1和IR对ECM硬度和成纤维细胞分化的影响。
We study the dynamics of tumor cell progression as growth factors and ionizing radiation (IR) combine to modify cellular microenvironments. Breast tumor growth depends on the behavior of cancer cells in their microenvironment, and both components are affected by IR fractionation parameters. TGF-β1 promotes differentiation of fibroblasts to myofibroblasts, which stiffens the extracellular matrix (ECM) and promotes malignant cell phenotypes. IR generates reactive oxygen species (ROS) that damages and inactivates cells thus controlling proliferation. The effects of TGF-β1 and IR at various fraction sizes on ECM stiffness and fibroblast differenation are studied using MRC-5 fibroblasts in 3-D collagen cultures.