Mitochondrial Calcification.
Mitochondrial Calcification.
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DOI：
10.20900/immunometab20210008
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Lood, Christian
中科院分区：
文献类型：
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作者：
Duvvuri, Bhargavi;Lood, Christian
线粒体最吸引人的方面之一是它们在磷酸盐存在下积累和储存大量钙的显着能力，导致线粒体钙化。在本文中，我们简要介绍了调节线粒体钙稳态的机制，然后对导致线粒体钙化的线粒体内磷酸钙颗粒的形成和表征及其与身体组织生理和病理钙化的相关性进行了广泛的综述。
One of the most fascinating aspects of mitochondria is their remarkable ability to accumulate and store large amounts of calcium in the presence of phosphate leading to mitochondrial calcification. In this paper, we briefly address the mechanisms that regulate mitochondrial calcium homeostasis followed by the extensive review on the formation and characterization of intramitochondrial calcium phosphate granules leading to mitochondrial calcification and its relevance to physiological and pathological calcifications of body tissues.